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Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.
Tang D, Sheng J, Xu L, Zhan X, Liu J, Jiang H, Shu X, Liu X, Zhang T, Jiang L, Zhou C, Li W, Cheng W, Li Z, Wang K, Lu K, Yan C, Qi S. Tang D, et al. Among authors: xu l. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9876-9883. doi: 10.1073/pnas.2002110117. Epub 2020 Apr 17. Proc Natl Acad Sci U S A. 2020. PMID: 32303654 Free PMC article.
The C9orf72-SMCR8-WDR41 complex is a GAP for small GTPases.
Tang D, Sheng J, Xu L, Yan C, Qi S. Tang D, et al. Among authors: xu l. Autophagy. 2020 Aug;16(8):1542-1543. doi: 10.1080/15548627.2020.1779473. Epub 2020 Jun 17. Autophagy. 2020. PMID: 32521185 Free PMC article.
ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis.
Tang D, Zheng K, Zhu J, Jin X, Bao H, Jiang L, Li H, Wang Y, Lu Y, Liu J, Liu H, Tang C, Feng S, Dong X, Xu L, Yin Y, Dang S, Wei X, Ren H, Dong B, Dai L, Cheng W, Wan M, Li Z, Chen J, Li H, Kong E, Wang K, Lu K, Qi S. Tang D, et al. Among authors: xu l. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2220496120. doi: 10.1073/pnas.2220496120. Epub 2023 Dec 8. Proc Natl Acad Sci U S A. 2023. PMID: 38064514 Free PMC article.
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