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Page 1
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4.
Prihandoko R, Kaur D, Wiegman CH, Alvarez-Curto E, Donovan C, Chachi L, Ulven T, Tyas MR, Euston E, Dong Z, Alharbi AGM, Kim RY, Lowe JG, Hansbro PM, Chung KF, Brightling CE, Milligan G, Tobin AB. Prihandoko R, et al. Among authors: chachi l. Sci Transl Med. 2020 Aug 19;12(557):eaaw9009. doi: 10.1126/scitranslmed.aaw9009. Sci Transl Med. 2020. PMID: 32817367 Free article.
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE. Saunders R, et al. Among authors: chachi l. Sci Transl Med. 2019 Feb 13;11(479):eaao6451. doi: 10.1126/scitranslmed.aao6451. Sci Transl Med. 2019. PMID: 30760581 Free article. Clinical Trial.
Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab.
George L, Wright A, Mistry V, Sutcliffe A, Chachi L, Haldar K, Ramsheh MY, Richardson M, van der Merwe R, Martin U, Newbold P, Brightling CE. George L, et al. Among authors: chachi l. Int J Chron Obstruct Pulmon Dis. 2019 Jun 5;14:1177-1185. doi: 10.2147/COPD.S198302. eCollection 2019. Int J Chron Obstruct Pulmon Dis. 2019. PMID: 31239655 Free PMC article. Clinical Trial.
Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.
Russell RJ, Chachi L, FitzGerald JM, Backer V, Olivenstein R, Titlestad IL, Ulrik CS, Harrison T, Singh D, Chaudhuri R, Leaker B, McGarvey L, Siddiqui S, Wang M, Braddock M, Nordenmark LH, Cohen D, Parikh H, Colice G, Brightling CE; MESOS study investigators. Russell RJ, et al. Among authors: chachi l. Lancet Respir Med. 2018 Jul;6(7):499-510. doi: 10.1016/S2213-2600(18)30201-7. Epub 2018 May 21. Lancet Respir Med. 2018. PMID: 29793857 Clinical Trial.
21 results