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Page 1
Pharmacological tools to target NKCC1 in brain disorders.
Savardi A, Borgogno M, De Vivo M, Cancedda L. Savardi A, et al. Trends Pharmacol Sci. 2021 Dec;42(12):1009-1034. doi: 10.1016/j.tips.2021.09.005. Epub 2021 Oct 4. Trends Pharmacol Sci. 2021. PMID: 34620512 Free article. Review.
Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome.
Borgogno M, Savardi A, Manigrasso J, Turci A, Portioli C, Ottonello G, Bertozzi SM, Armirotti A, Contestabile A, Cancedda L, De Vivo M. Borgogno M, et al. Among authors: savardi a. J Med Chem. 2021 Jul 22;64(14):10203-10229. doi: 10.1021/acs.jmedchem.1c00603. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34137257 Free PMC article.
APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.
Piccini A, Castroflorio E, Valente P, Guarnieri FC, Aprile D, Michetti C, Bramini M, Giansante G, Pinto B, Savardi A, Cesca F, Bachi A, Cattaneo A, Wren JD, Fassio A, Valtorta F, Benfenati F, Giovedì S. Piccini A, et al. Among authors: savardi a. Cell Rep. 2017 Dec 19;21(12):3596-3611. doi: 10.1016/j.celrep.2017.11.073. Cell Rep. 2017. PMID: 29262337 Free article.
Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target.
Potenzieri A, Uccella S, Preiti D, Pisoni M, Rosati S, Lavarello C, Bartolucci M, Debellis D, Catalano F, Petretto A, Nobili L, Fellin T, Tucci V, Ramenghi LA, Savardi A, Cancedda L. Potenzieri A, et al. Among authors: savardi a. Sci Adv. 2024 Mar;10(9):eadk8123. doi: 10.1126/sciadv.adk8123. Epub 2024 Mar 1. Sci Adv. 2024. PMID: 38427732 Free PMC article.