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A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
Le Tourneau C, Delord JP, Kotecki N, Borcoman E, Gomez-Roca C, Hescot S, Jungels C, Vincent-Salomon A, Cockenpot V, Eberst L, Molé A, Jdey W, Bono F, Trochon-Joseph V, Toussaint H, Zandanel C, Adamiec O, de Beaumont O, Cassier PA. Le Tourneau C, et al. Among authors: eberst l. Br J Cancer. 2020 Nov;123(10):1481-1489. doi: 10.1038/s41416-020-01028-8. Epub 2020 Aug 25. Br J Cancer. 2020. PMID: 32839491 Free PMC article. Clinical Trial.
The off-label use of targeted therapies in sarcomas: the OUTC'S program.
Eberst L, Cropet C, Le Cesne A, Pautier P, Penel N, Adenis A, Chevreau C, Bay JO, Collard O, Cupissol D, Duffaud F, Gentet JC, Piperno-Neumann S, Marec-Berard P, Bompas E, Thyss A, Chaigneau L, Cassier P, Bertucci F, Blay JY, Ray-Coquard I. Eberst L, et al. BMC Cancer. 2014 Nov 24;14:870. doi: 10.1186/1471-2407-14-870. BMC Cancer. 2014. PMID: 25420707 Free PMC article. Clinical Trial.
[Therapeutic targeting of Notch signaling in cancer].
Brahmi M, Bally O, Eberst L, Cassier P. Brahmi M, et al. Among authors: eberst l. Bull Cancer. 2017 Oct;104(10):883-891. doi: 10.1016/j.bulcan.2017.07.007. Epub 2017 Oct 12. Bull Cancer. 2017. PMID: 29031504 Review. French.
[DNA repair as a therapeutic target].
Eberst L, Brahmi M, Cassier PA. Eberst L, et al. Bull Cancer. 2017 Nov;104(11):988-998. doi: 10.1016/j.bulcan.2017.09.005. Epub 2017 Nov 11. Bull Cancer. 2017. PMID: 29132681 Review. French.
Phase I Study of Ramucirumab Plus Merestinib in Previously Treated Metastatic Colorectal Cancer: Safety, Preliminary Efficacy, and Pharmacokinetic Findings.
Saleh M, Cassier PA, Eberst L, Naik G, Morris VK, Pant S, Terret C, Gao L, Long A, Mao H, McNeely S, Wagner EK, Carlesi RM, Fu S. Saleh M, et al. Among authors: eberst l. Oncologist. 2020 Nov;25(11):e1628-e1639. doi: 10.1634/theoncologist.2020-0520. Epub 2020 Jul 17. Oncologist. 2020. PMID: 32537847 Free PMC article. Clinical Trial.
Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial.
Arnaud-Coffin P, Brahmi M, Vanacker H, Eberst L, Tredan O, Attignon V, Pissaloux D, Sohier E, Cassier P, Garin G, Pérol D, Blay JY, Dufresne A. Arnaud-Coffin P, et al. Among authors: eberst l. Transl Oncol. 2020 Dec;13(12):100870. doi: 10.1016/j.tranon.2020.100870. Epub 2020 Sep 18. Transl Oncol. 2020. PMID: 32950930 Free PMC article.
Phase Ib study of anti-CSF-1R antibody emactuzumab in combination with CD40 agonist selicrelumab in advanced solid tumor patients.
Machiels JP, Gomez-Roca C, Michot JM, Zamarin D, Mitchell T, Catala G, Eberst L, Jacob W, Jegg AM, Cannarile MA, Watson C, Babitzki G, Korski K, Klaman I, Teixeira P, Hoves S, Ries C, Meneses-Lorente G, Michielin F, Christen R, Rüttinger D, Weisser M, Delord JP, Cassier P. Machiels JP, et al. Among authors: eberst l. J Immunother Cancer. 2020 Oct;8(2):e001153. doi: 10.1136/jitc-2020-001153. J Immunother Cancer. 2020. PMID: 33097612 Free PMC article. Clinical Trial.
35 results