Holder JR - Search Results

1

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.

Reed AB, Lanman BA, Holder JR, Yang BH, Ma J, Humphreys SC, Wang Z, Chan JCY, Miranda LP, Swaminath G, Allen JG. Reed AB, et al. Among authors: holder jr. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127499. doi: 10.1016/j.bmcl.2020.127499. Epub 2020 Aug 26. Bioorg Med Chem Lett. 2020. PMID: 32858124

2

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. Among authors: holder jr. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16. Bioorg Med Chem Lett. 2015. PMID: 26112439

3

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K. Miranda LP, et al. Among authors: holder jr. J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298. J Med Chem. 2008. PMID: 19053766

4

Direct quantitative analysis of a 20 kDa PEGylated human calcitonin gene peptide antagonist in cynomolgus monkey serum using in-source CID and UPLC-MS/MS.

Li H, Rose MJ, Holder JR, Wright M, Miranda LP, James CA. Li H, et al. Among authors: holder jr. J Am Soc Mass Spectrom. 2011 Sep;22(9):1660-7. doi: 10.1007/s13361-011-0180-2. Epub 2011 Jun 23. J Am Soc Mass Spectrom. 2011. PMID: 21953269

5

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.

Miranda LP, Shi L, Holder JR, Wright M, Gegg CV, Johnson E, Wild K, Stenkilsson M, Doellgast G, Manning BH, Salyers K. Miranda LP, et al. Among authors: holder jr. Biopolymers. 2013 Jul;100(4):422-30. doi: 10.1002/bip.22270. Biopolymers. 2013. PMID: 23868210

6

Engineering Antibody Reactivity for Efficient Derivatization to Generate Na_V1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.

Biswas K, Nixey TE, Murray JK, Falsey JR, Yin L, Liu H, Gingras J, Hall BE, Herberich B, Holder JR, Li H, Ligutti J, Lin MJ, Liu D, Soriano BD, Soto M, Tran L, Tegley CM, Zou A, Gunasekaran K, Moyer BD, Doherty L, Miranda LP. Biswas K, et al. Among authors: holder jr. ACS Chem Biol. 2017 Sep 15;12(9):2427-2435. doi: 10.1021/acschembio.7b00542. Epub 2017 Aug 28. ACS Chem Biol. 2017. PMID: 28800217

7

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position.

Holder JR, Xiang Z, Bauzo RM, Haskell-Luevano C. Holder JR, et al. J Med Chem. 2002 Dec 19;45(26):5736-44. doi: 10.1021/jm020296e. J Med Chem. 2002. PMID: 12477357

8

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.

Holder JR, Bauzo RM, Xiang Z, Scott J, Haskell-Luevano C. Holder JR, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4505-9. doi: 10.1016/j.bmcl.2003.08.078. Bioorg Med Chem Lett. 2003. PMID: 14643357

9

N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes.

Todorovic A, Holder JR, Bauzo RM, Scott JW, Kavanagh R, Abdel-Malek Z, Haskell-Luevano C. Todorovic A, et al. Among authors: holder jr. J Med Chem. 2005 May 5;48(9):3328-36. doi: 10.1021/jm0490843. J Med Chem. 2005. PMID: 15857138

10

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.

Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C. Holder JR, et al. J Med Chem. 2002 Jul 4;45(14):3073-81. doi: 10.1021/jm010524p. J Med Chem. 2002. PMID: 12086493

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