Covey DF - Search Results

1

The T-type calcium channel isoform Ca_v3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile.

Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Timic Stamenic T, et al. Among authors: covey df. Br J Anaesth. 2021 Jan;126(1):245-255. doi: 10.1016/j.bja.2020.07.022. Epub 2020 Aug 25. Br J Anaesth. 2021. PMID: 32859366 Free PMC article.

2

The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.

Nakashima YM, Todorovic SM, Covey DF, Lingle CJ. Nakashima YM, et al. Among authors: covey df. Mol Pharmacol. 1998 Sep;54(3):559-68. doi: 10.1124/mol.54.3.559. Mol Pharmacol. 1998. PMID: 9730915

3

Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.

Todorovic SM, Prakriya M, Nakashima YM, Nilsson KR, Han M, Zorumski CF, Covey DF, Lingle CJ. Todorovic SM, et al. Among authors: covey df. Mol Pharmacol. 1998 Nov;54(5):918-27. doi: 10.1124/mol.54.5.918. Mol Pharmacol. 1998. PMID: 9804627

4

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.

Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. Todorovic SM, et al. Among authors: covey df. Mol Pharmacol. 2004 Nov;66(5):1223-35. doi: 10.1124/mol.104.002402. Epub 2004 Jul 27. Mol Pharmacol. 2004. PMID: 15280444

5

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.

Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Pathirathna S, et al. Among authors: covey df. Pain. 2005 Apr;114(3):429-443. doi: 10.1016/j.pain.2005.01.009. Pain. 2005. PMID: 15777868

6

5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain.

Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. Pathirathna S, et al. Among authors: covey df. Pain. 2005 Oct;117(3):326-339. doi: 10.1016/j.pain.2005.06.019. Pain. 2005. PMID: 16150542

7

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats.

Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Pathirathna S, et al. Among authors: covey df. Pain. 2006 Nov;125(1-2):53-64. doi: 10.1016/j.pain.2006.04.024. Epub 2006 Jun 19. Pain. 2006. PMID: 16782275

8

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Katona BW, et al. Among authors: covey df. Eur J Med Chem. 2008 Jan;43(1):107-13. doi: 10.1016/j.ejmech.2007.02.017. Epub 2007 Mar 12. Eur J Med Chem. 2008. PMID: 17434649

9

Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol.

Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A. Kelley SP, et al. Among authors: covey df. Eur J Pharmacol. 2007 Oct 31;572(2-3):94-101. doi: 10.1016/j.ejphar.2007.06.028. Epub 2007 Jun 29. Eur J Pharmacol. 2007. PMID: 17658511 Free PMC article.

10

GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices.

Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF. Izumi Y, et al. Among authors: covey df. Eur J Neurosci. 2007 Oct;26(7):1881-8. doi: 10.1111/j.1460-9568.2007.05809.x. Epub 2007 Sep 20. Eur J Neurosci. 2007. PMID: 17883414

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