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Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Vargas HM, Rolf MG, Wisialowski TA, Achanzar W, Bahinski A, Bass A, Benson CT, Chaudhary KW, Couvreur N, Dota C, Engwall MJ, Michael Foley C, Gallacher D, Greiter-Wilke A, Guillon JM, Guth B, Himmel HM, Hegele-Hartung C, Ito M, Jenkinson S, Chiba K, Lagrutta A, Levesque P, Martel E, Okai Y, Peri R, Pointon A, Qu Y, Teisman A, Traebert M, Yoshinaga T, Gintant GA, Leishman DJ, Valentin JP. Vargas HM, et al. Among authors: pointon a. Clin Pharmacol Ther. 2021 Feb;109(2):310-318. doi: 10.1002/cpt.2029. Epub 2020 Sep 24. Clin Pharmacol Ther. 2021. PMID: 32866317 Free PMC article. Review.
Preservation of cardiomyocytes from the adult heart.
Abi-Gerges N, Pointon A, Pullen GF, Morton MJ, Oldman KL, Armstrong D, Valentin JP, Pollard CE. Abi-Gerges N, et al. Among authors: pointon a. J Mol Cell Cardiol. 2013 Nov;64:108-19. doi: 10.1016/j.yjmcc.2013.09.004. Epub 2013 Sep 16. J Mol Cell Cardiol. 2013. PMID: 24051370
Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes.
Abi-Gerges N, Pointon A, Oldman KL, Brown MR, Pilling MA, Sefton CE, Garside H, Pollard CE. Abi-Gerges N, et al. Among authors: pointon a. J Pharmacol Toxicol Methods. 2017 Jan-Feb;83:1-15. doi: 10.1016/j.vascn.2016.09.001. Epub 2016 Sep 10. J Pharmacol Toxicol Methods. 2017. PMID: 27622857
In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities.
Bassan A, Alves VM, Amberg A, Anger LT, Beilke L, Bender A, Bernal A, Cronin MTD, Hsieh JH, Johnson C, Kemper R, Mumtaz M, Neilson L, Pavan M, Pointon A, Pletz J, Ruiz P, Russo DP, Sabnis Y, Sandhu R, Schaefer M, Stavitskaya L, Szabo DT, Valentin JP, Woolley D, Zwickl C, Myatt GJ. Bassan A, et al. Among authors: pointon a. Comput Toxicol. 2021 Nov;20:100188. doi: 10.1016/j.comtox.2021.100188. Epub 2021 Sep 13. Comput Toxicol. 2021. PMID: 35721273 Free PMC article.
Drug-induced myocardial dysfunction - recommendations for assessment in clinical and pre-clinical studies.
Ebrahimi A, Raichlen JS, Pointon A, Gottfridsson C, Munley J, Hockings P, Cartwright J, Buss N, Wikström J, Gan LM, Whittaker A, Khalil A, George RT, Garkaviy P, Brott D. Ebrahimi A, et al. Among authors: pointon a. Expert Opin Drug Saf. 2020 Mar;19(3):281-294. doi: 10.1080/14740338.2020.1731471. Epub 2020 Feb 25. Expert Opin Drug Saf. 2020. PMID: 32064957 Review.
69 results