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Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.
Khanna D, Lin CJF, Furst DE, Goldin J, Kim G, Kuwana M, Allanore Y, Matucci-Cerinic M, Distler O, Shima Y, van Laar JM, Spotswood H, Wagner B, Siegel J, Jahreis A, Denton CP; focuSSced investigators. Khanna D, et al. Among authors: distler o. Lancet Respir Med. 2020 Oct;8(10):963-974. doi: 10.1016/S2213-2600(20)30318-0. Epub 2020 Aug 28. Lancet Respir Med. 2020. PMID: 32866440 Clinical Trial.
Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: a newly identified pathway to skin inflammation in systemic sclerosis.
Kowal-Bielecka O, Distler O, Neidhart M, Künzler P, Rethage J, Nawrath M, Carossino A, Pap T, Müller-Ladner U, Michel BA, Sierakowski S, Matucci-Cerinic M, Gay RE, Gay S. Kowal-Bielecka O, et al. Among authors: distler o. Arthritis Rheum. 2001 Aug;44(8):1865-75. doi: 10.1002/1529-0131(200108)44:8<1865::AID-ART325>3.0.CO;2-M. Arthritis Rheum. 2001. PMID: 11508440 Free article.
Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis.
Distler O, Pap T, Kowal-Bielecka O, Meyringer R, Guiducci S, Landthaler M, Schölmerich J, Michel BA, Gay RE, Matucci-Cerinic M, Gay S, Müller-Ladner U. Distler O, et al. Arthritis Rheum. 2001 Nov;44(11):2665-78. doi: 10.1002/1529-0131(200111)44:11<2665::aid-art446>3.0.co;2-s. Arthritis Rheum. 2001. PMID: 11710722 Free article.
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.
Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S, Gay RE, Michel BA, Brühlmann P, Müller-Ladner U, Gay S, Matucci-Cerinic M. Distler O, et al. Arthritis Res. 2002;4(6):R11. doi: 10.1186/ar596. Epub 2002 Aug 30. Arthritis Res. 2002. PMID: 12453314 Free PMC article.
Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.
Distler JH, Hagen C, Hirth A, Müller-Ladner U, Lorenz HM, del Rosso A, Michel BA, Gay RE, Nanagara R, Nishioka K, Matucci-Cerinic M, Kalden JR, Gay S, Distler O. Distler JH, et al. Among authors: distler o. Mol Pharmacol. 2004 Feb;65(2):389-99. doi: 10.1124/mol.65.2.389. Mol Pharmacol. 2004. PMID: 14742681
Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.
Distler O, Distler JH, Scheid A, Acker T, Hirth A, Rethage J, Michel BA, Gay RE, Müller-Ladner U, Matucci-Cerinic M, Plate KH, Gassmann M, Gay S. Distler O, et al. Among authors: distler jh. Circ Res. 2004 Jul 9;95(1):109-16. doi: 10.1161/01.RES.0000134644.89917.96. Epub 2004 Jun 3. Circ Res. 2004. PMID: 15178641
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.
Distler JH, Jüngel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Müller-Ladner U, Lorenz HM, Gay S, Distler O. Distler JH, et al. Among authors: distler o. Arthritis Rheum. 2005 Mar;52(3):856-64. doi: 10.1002/art.20883. Arthritis Rheum. 2005. PMID: 15751077 Free article.
Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells.
Distler JH, Jüngel A, Caretto D, Schulze-Horsel U, Kowal-Bielecka O, Gay RE, Michel BA, Müller-Ladner U, Kalden JR, Gay S, Distler O. Distler JH, et al. Among authors: distler o. Arthritis Rheum. 2006 Jan;54(1):214-25. doi: 10.1002/art.21497. Arthritis Rheum. 2006. PMID: 16385517 Free article.
670 results