Smeltz MG - Search Results

1

Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.

Squirewell EJ, Smeltz MG, Rowland-Faux L, Horne LP, Stacpoole PW, James MO. Squirewell EJ, et al. Among authors: smeltz mg. Drug Metab Dispos. 2020 Nov;48(11):1217-1223. doi: 10.1124/dmd.120.000142. Epub 2020 Sep 1. Drug Metab Dispos. 2020. PMID: 32873593 Free PMC article.

2

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. James MO, et al. Among authors: smeltz mg. Pharmacol Ther. 2017 Feb;170:166-180. doi: 10.1016/j.pharmthera.2016.10.018. Epub 2016 Oct 19. Pharmacol Ther. 2017. PMID: 27771434 Free PMC article. Review.

3

Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.

Jahn SC, Smeltz MG, Hu Z, Rowland-Faux L, Zhong G, Lorenzo RJ, Cisneros KV, Stacpoole PW, James MO. Jahn SC, et al. Among authors: smeltz mg. Biochem Pharmacol. 2018 Jun;152:236-243. doi: 10.1016/j.bcp.2018.04.001. Epub 2018 Apr 5. Biochem Pharmacol. 2018. PMID: 29626439 Free PMC article.

4

Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW. Zhong G, et al. Among authors: smeltz mg. Drug Metab Dispos. 2018 Aug;46(8):1118-1128. doi: 10.1124/dmd.118.081810. Epub 2018 May 31. Drug Metab Dispos. 2018. PMID: 29853471 Free PMC article.

5

Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.

Smeltz MG, Hu Z, Zhong G, Jahn SC, Rowland-Faux L, Horne LP, Stacpoole PW, James MO. Smeltz MG, et al. Chem Res Toxicol. 2019 Oct 21;32(10):2042-2052. doi: 10.1021/acs.chemrestox.9b00207. Epub 2019 Oct 1. Chem Res Toxicol. 2019. PMID: 31524376 Free PMC article.

6

Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a).

Boone CD, Zhong G, Smeltz M, James MO, McKenna R. Boone CD, et al. Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):187-9. doi: 10.1107/S2053230X13033591. Epub 2014 Jan 21. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24637752 Free PMC article.

7

A multi-year study of hepatic biomarkers in coastal fishes from the Gulf of Mexico after the Deepwater Horizon Oil Spill.

Smeltz M, Rowland-Faux L, Ghiran C, Patterson WF 3rd, Garner SB, Beers A, Mièvre Q, Kane AS, James MO. Smeltz M, et al. Mar Environ Res. 2017 Aug;129:57-67. doi: 10.1016/j.marenvres.2017.04.015. Epub 2017 Apr 27. Mar Environ Res. 2017. PMID: 28487163

8

Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure.

Houck KA, Patlewicz G, Richard AM, Williams AJ, Shobair MA, Smeltz M, Clifton MS, Wetmore B, Medvedev A, Makarov S. Houck KA, et al. Toxicology. 2021 Jun 15;457:152789. doi: 10.1016/j.tox.2021.152789. Epub 2021 Apr 20. Toxicology. 2021. PMID: 33887376

9

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells.

Houck KA, Friedman KP, Feshuk M, Patlewicz G, Smeltz M, Clifton MS, Wetmore BA, Velichko S, Berenyi A, Berg EL. Houck KA, et al. ALTEX. 2023;40(2):248–270. doi: 10.14573/altex.2203041. Epub 2022 Sep 15. ALTEX. 2023. PMID: 36129398 Free PMC article.

10

The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.

Beames T, Moreau M, Roberts LA, Mansouri K, Haider S, Smeltz M, Nicolas CI, Doheny D, Phillips MB, Yoon M, Becker RA, McMullen PD, Andersen ME, Clewell RA, Hartman JK. Beames T, et al. Toxicol Appl Pharmacol. 2020 Jan 15;387:114774. doi: 10.1016/j.taap.2019.114774. Epub 2019 Nov 27. Toxicol Appl Pharmacol. 2020. PMID: 31783037 Free article.

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