Wang W - Search Results

1

G551D mutation impairs PKA-dependent activation of CFTR channel that can be restored by novel GOF mutations.

Wang W, Fu L, Liu Z, Wen H, Rab A, Hong JS, Kirk KL, Rowe SM. Wang W, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Nov 1;319(5):L770-L785. doi: 10.1152/ajplung.00262.2019. Epub 2020 Sep 2. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32877225 Free PMC article.

2

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.

Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, Sorscher EJ. Ehrhardt A, et al. Among authors: wang w. J Biol Chem. 2016 Jan 22;291(4):1854-1865. doi: 10.1074/jbc.M115.704809. Epub 2015 Dec 1. J Biol Chem. 2016. PMID: 26627831 Free PMC article.

3

Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators.

Wang W, Hong JS, Rab A, Sorscher EJ, Kirk KL. Wang W, et al. PLoS One. 2016 Mar 23;11(3):e0152232. doi: 10.1371/journal.pone.0152232. eCollection 2016. PLoS One. 2016. PMID: 27007499 Free PMC article.

4

Slowing ribosome velocity restores folding and function of mutant CFTR.

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL 4th, Ignatova Z, Sorscher EJ. Oliver KE, et al. Among authors: wang w. J Clin Invest. 2019 Dec 2;129(12):5236-5253. doi: 10.1172/JCI124282. J Clin Invest. 2019. PMID: 31657788 Free PMC article.

5

Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains.

Wang W, Bernard K, Li G, Kirk KL. Wang W, et al. J Biol Chem. 2007 Feb 16;282(7):4533-4544. doi: 10.1074/jbc.M609942200. Epub 2006 Dec 18. J Biol Chem. 2007. PMID: 17178710 Free article.

6

A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter.

Kirk KL, Wang W. Kirk KL, et al. Among authors: wang w. J Biol Chem. 2011 Apr 15;286(15):12813-9. doi: 10.1074/jbc.R111.219634. Epub 2011 Feb 4. J Biol Chem. 2011. PMID: 21296873 Free PMC article. Review.

7

Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.

Wang W, Okeyo GO, Tao B, Hong JS, Kirk KL. Wang W, et al. J Biol Chem. 2011 Dec 9;286(49):41937-41948. doi: 10.1074/jbc.M111.296061. Epub 2011 Sep 30. J Biol Chem. 2011. PMID: 21965669 Free PMC article.

8

Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations.

Okeyo G, Wang W, Wei S, Kirk KL. Okeyo G, et al. Among authors: wang w. J Biol Chem. 2013 Jun 14;288(24):17122-33. doi: 10.1074/jbc.M112.442582. Epub 2013 Apr 25. J Biol Chem. 2013. PMID: 23620589 Free PMC article.

9

An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.

Wang W, Roessler BC, Kirk KL. Wang W, et al. J Biol Chem. 2014 Oct 31;289(44):30364-30378. doi: 10.1074/jbc.M114.595710. Epub 2014 Sep 4. J Biol Chem. 2014. PMID: 25190805 Free PMC article.

10

The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke.

Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes JC, DeLucas LJ, Barnes S, Kirk K, Tearney GJ, Rowe SM. Raju SV, et al. Among authors: wang w. Am J Respir Cell Mol Biol. 2017 Jan;56(1):99-108. doi: 10.1165/rcmb.2016-0226OC. Am J Respir Cell Mol Biol. 2017. PMID: 27585394 Free PMC article.

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