KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-κB-FGF21 or SREBP1c-FGF21 pathway.
Zhou L, Li Q, Chen A, Liu N, Chen N, Chen X, Zhu L, Xia B, Gong Y, Chen X.
Zhou L, et al. Among authors: chen n, chen a, chen x.
FASEB J. 2019 Dec;33(12):14254-14269. doi: 10.1096/fj.201901347RR. Epub 2019 Oct 24.
FASEB J. 2019.
PMID: 31648561
Together, our studies identify an important role and regulation mechanism of TWIST2 in maintaining hepatic homeostasis by ameliorating steatosis, inflammation, and oxidative stress via the NF-kappaB-FGF21 or SREBP1c-FGF21 pathway, which may provide a new therapeutic scheme for no …
Together, our studies identify an important role and regulation mechanism of TWIST2 in maintaining hepatic homeostasis by ameliorating steat …