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Page 1
Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody-Drug Conjugate.
Cheng H, Cong Q, Dervin D, Stevens A, Vemuri K, Huber M, Juliano J, Cuison S, Sung J, Passmore D, Chong C, Greenbaum M, Kwok E, Jiang J, Pan C, Rao-Naik C, Rangan V, Kempe T, Tatum A, Deshpande S, Cardarelli P, Vite G, Gangwar S. Cheng H, et al. Among authors: rangan v. Bioconjug Chem. 2020 Oct 21;31(10):2350-2361. doi: 10.1021/acs.bioconjchem.0c00429. Epub 2020 Sep 11. Bioconjug Chem. 2020. PMID: 32881482
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Poudel YB, Rao C, Kotapati S, Deshpande M, Thevanayagam L, Pan C, Cardarelli J, Chowdari N, Kaspady M, Samikannu R, Kuppusamy P, Saravanakumar P, Arunachalam PN, Deshpande S, Rangan V, Rampulla R, Mathur A, Vite GD, Gangwar S. Poudel YB, et al. Among authors: rangan v. Bioorg Med Chem Lett. 2020 Jan 1;30(1):126782. doi: 10.1016/j.bmcl.2019.126782. Epub 2019 Nov 9. Bioorg Med Chem Lett. 2020. PMID: 31767265
Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.
Chowdari NS, Zhang Y, McDonald I, Johnson W, Langley DR, Sivaprakasam P, Mate R, Huynh T, Kotapati S, Deshpande M, Pan C, Menezes D, Wang Y, Rao C, Sarma G, Warrack BM, Rangan VS, Mei-Chen S, Cardarelli P, Deshpande S, Passmore D, Rampulla R, Mathur A, Borzilleri R, Rajpal A, Vite G, Gangwar S. Chowdari NS, et al. J Med Chem. 2020 Nov 25;63(22):13913-13950. doi: 10.1021/acs.jmedchem.0c01385. Epub 2020 Nov 6. J Med Chem. 2020. PMID: 33155811
Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans.
Wang H, Rangan VS, Sung MC, Passmore D, Kempe T, Wang X, Thevanayagam L, Pan C, Rao C, Srinivasan M, Zhang Q, Gangwar S, Deshpande S, Cardarelli P, Marathe P, Yang Z. Wang H, et al. Biopharm Drug Dispos. 2016 Mar;37(2):93-106. doi: 10.1002/bdd.1953. Epub 2015 May 15. Biopharm Drug Dispos. 2016. PMID: 25869904
An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.
Myler H, Rangan VS, Wang J, Kozhich A, Cummings JA, Neely R, Dail D, Liu A, Wang B, Vezina HE, Freebern W, Sung MC, Passmore D, Deshpande S, Kempe T, Gu H, Saewert M, Manney A, Lute J, Zambito F, Wong RL, Piccoli SP, Aubry AF, Pillutla R, Arnold M, DeSilva B. Myler H, et al. Bioanalysis. 2015;7(13):1569-82. doi: 10.4155/bio.15.80. Bioanalysis. 2015. PMID: 26226308
A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer.
Ponath P, Menezes D, Pan C, Chen B, Oyasu M, Strachan D, LeBlanc H, Sun H, Wang XT, Rangan VS, Deshpande S, Cristea S, Park KS, Sage J, Cardarelli PM. Ponath P, et al. Clin Cancer Res. 2018 Oct 15;24(20):5178-5189. doi: 10.1158/1078-0432.CCR-18-0018. Epub 2018 Jul 18. Clin Cancer Res. 2018. PMID: 30021910 Free PMC article.
130 results