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Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
Pirrone MG, Gysin M, Haldimann K, Hobbie SN, Vasella A, Crich D. Pirrone MG, et al. Among authors: crich d. J Org Chem. 2020 Dec 18;85(24):16043-16059. doi: 10.1021/acs.joc.0c01836. Epub 2020 Sep 23. J Org Chem. 2020. PMID: 32902280 Free PMC article.
Block synthesis of tetra- and hexasaccharides (beta-D-glycero-D-manno-Hep p-(1-->4)-[alpha-l-Rha p-(1-->3)-beta-D-glycero-D-manno-Hep p-(1-->4)]n-alpha-L-Rha p-OMe (n = 1 and 2)) corresponding to multiple repeat units of the glycan from the surface-layer glycoprotein from Bacillus thermoaerophilus.
Crich D, Li M. Crich D, et al. J Org Chem. 2008 Sep 19;73(18):7003-10. doi: 10.1021/jo801414c. Epub 2008 Aug 27. J Org Chem. 2008. PMID: 18729513 Free PMC article.
Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC. Duscha S, et al. Among authors: crich d. mBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14. mBio. 2014. PMID: 25271289 Free PMC article.
280 results