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Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drayman N, et al. Among authors: heaton ns. bioRxiv [Preprint]. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. bioRxiv. 2020. Update in: Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827 PMID: 32908976 Free PMC article. Updated. Preprint.
Multifaceted roles for lipids in viral infection.
Heaton NS, Randall G. Heaton NS, et al. Trends Microbiol. 2011 Jul;19(7):368-75. doi: 10.1016/j.tim.2011.03.007. Epub 2011 Apr 29. Trends Microbiol. 2011. PMID: 21530270 Free PMC article. Review.
Dengue virus and autophagy.
Heaton NS, Randall G. Heaton NS, et al. Viruses. 2011 Aug;3(8):1332-41. doi: 10.3390/v3081332. Epub 2011 Aug 4. Viruses. 2011. PMID: 21994782 Free PMC article. Review.
Lipids at the interface of virus-host interactions.
Chukkapalli V, Heaton NS, Randall G. Chukkapalli V, et al. Among authors: heaton ns. Curr Opin Microbiol. 2012 Aug;15(4):512-8. doi: 10.1016/j.mib.2012.05.013. Epub 2012 Jun 9. Curr Opin Microbiol. 2012. PMID: 22682978 Free PMC article. Review.
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Drayman N, et al. Among authors: heaton ns. Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827. Epub 2021 Jul 20. Science. 2021. PMID: 34285133 Free PMC article.
72 results