Cheng J - Search Results

1

Tumor Immunotherapy Using A_2A Adenosine Receptor Antagonists.

Zhang J, Yan W, Duan W, Wüthrich K, Cheng J. Zhang J, et al. Among authors: cheng j. Pharmaceuticals (Basel). 2020 Sep 8;13(9):237. doi: 10.3390/ph13090237. Pharmaceuticals (Basel). 2020. PMID: 32911819 Free PMC article. Review.

2

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Tan L, Yan W, McCorvy JD, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2018 Nov 21;61(22):9841-9878. doi: 10.1021/acs.jmedchem.8b00435. Epub 2018 Jul 10. J Med Chem. 2018. PMID: 29939744 Review.

3

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

Tan L, Zhou Q, Yan W, Sun J, Kozikowski AP, Zhao S, Huang XP, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2020 May 14;63(9):4579-4602. doi: 10.1021/acs.jmedchem.9b01835. Epub 2020 Apr 23. J Med Chem. 2020. PMID: 32282200

4

Revisit ligand-receptor interaction at the human vasopressin V₂ receptor: A kinetic perspective.

Liu C, Xia L, Fu K, Cao X, Yan W, Cheng J, Roux T, Peletier LA, Yin X, Guo D. Liu C, et al. Among authors: cheng j. Eur J Pharmacol. 2020 Aug 5;880:173157. doi: 10.1016/j.ejphar.2020.173157. Epub 2020 Apr 30. Eur J Pharmacol. 2020. PMID: 32360346

5

Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis.

Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Duan W, et al. Among authors: cheng j. Eur J Med Chem. 2021 Dec 15;226:113878. doi: 10.1016/j.ejmech.2021.113878. Epub 2021 Oct 5. Eur J Med Chem. 2021. PMID: 34634742

6

Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A_2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents.

Yan W, Ling L, Wu Y, Yang K, Liu R, Zhang J, Zhao S, Zhong G, Zhao S, Jiang H, Xie C, Cheng J. Yan W, et al. Among authors: cheng j. J Med Chem. 2021 Nov 25;64(22):16573-16597. doi: 10.1021/acs.jmedchem.1c01155. Epub 2021 Nov 16. J Med Chem. 2021. PMID: 34783558

7

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D₂ Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation.

Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. Yan W, et al. Among authors: cheng j. J Med Chem. 2021 Dec 9;64(23):17239-17258. doi: 10.1021/acs.jmedchem.1c01327. Epub 2021 Nov 19. J Med Chem. 2021. PMID: 34797051

8

Long Residence Time at the Vasopressin V₂ Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease.

Zhang H, Yan W, Sun Y, Yuan H, Su L, Cao X, Wang P, Xu Z, Hu Y, Wang Z, Wang Y, Fu K, Sun Y, Chen Y, Cheng J, Guo D. Zhang H, et al. Among authors: cheng j. J Med Chem. 2022 Jun 9;65(11):7717-7728. doi: 10.1021/acs.jmedchem.2c00011. Epub 2022 Apr 1. J Med Chem. 2022. PMID: 35363466

9

Dual-acting antitumor agents targeting the A_2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives.

Zhang J, Luo Z, Duan W, Yang K, Ling L, Yan W, Liu R, Wüthrich K, Jiang H, Xie C, Cheng J. Zhang J, et al. Among authors: cheng j. Eur J Med Chem. 2022 Jun 5;236:114326. doi: 10.1016/j.ejmech.2022.114326. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35390714

10

Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V₂ Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD.

Gu X, Yuan H, Zhao W, Sun N, Yan W, Jiang C, He Y, Liu H, Cheng J, Guo D. Gu X, et al. Among authors: cheng j. J Med Chem. 2023 Jan 26;66(2):1454-1466. doi: 10.1021/acs.jmedchem.2c01625. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36563185

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