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Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.
Soncini D, Minetto P, Martinuzzi C, Becherini P, Fenu V, Guolo F, Todoerti K, Calice G, Contini P, Miglino M, Rivoli G, Aquino S, Dominietto A, Cagnetta A, Passalacqua M, Bruzzone S, Nencioni A, Zucchetti M, Ceruti T, Neri A, Lemoli RM, Cea M. Soncini D, et al. Among authors: fenu v. Blood Adv. 2020 Sep 22;4(18):4312-4326. doi: 10.1182/bloodadvances.2020001639. Blood Adv. 2020. PMID: 32915979 Free PMC article.