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The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.
Berquez M, Gadsby JR, Festa BP, Butler R, Jackson SP, Berno V, Luciani A, Devuyst O, Gallop JL. Berquez M, et al. Among authors: gadsby jr. Kidney Int. 2020 Oct;98(4):883-896. doi: 10.1016/j.kint.2020.05.040. Epub 2020 Sep 9. Kidney Int. 2020. PMID: 32919786 Free PMC article.
A direct role for SNX9 in the biogenesis of filopodia.
Jarsch IK, Gadsby JR, Nuccitelli A, Mason J, Shimo H, Pilloux L, Marzook B, Mulvey CM, Dobramysl U, Bradshaw CR, Lilley KS, Hayward RD, Vaughan TJ, Dobson CL, Gallop JL. Jarsch IK, et al. Among authors: gadsby jr. J Cell Biol. 2020 Apr 6;219(4):e201909178. doi: 10.1083/jcb.201909178. J Cell Biol. 2020. PMID: 32328641 Free PMC article.