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Secukinumab provided significant and sustained improvement in the signs and symptoms of ankylosing spondylitis: results from the 52-week, Phase III China-centric study, MEASURE 5.
Huang F, Sun F, Wan WG, Wu LJ, Dong LL, Zhang X, Kim TH, Sengupta R, Šenolt L, Wang Y, Qiu HM, Porter B, Haemmerle S. Huang F, et al. Among authors: senolt l. Chin Med J (Engl). 2020 Nov 5;133(21):2521-2531. doi: 10.1097/CM9.0000000000001099. Chin Med J (Engl). 2020. PMID: 32925287 Free PMC article. Clinical Trial.
New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis.
Navrátilová A, Bečvář V, Hulejová H, Tomčík M, Štolová L, Mann H, Růžičková O, Šléglová O, Závada J, Pavelka K, Vencovský J, Šenolt L, Andrés Cerezo L. Navrátilová A, et al. Among authors: senolt l. RMD Open. 2023 May;9(2):e002894. doi: 10.1136/rmdopen-2022-002894. RMD Open. 2023. PMID: 37208028 Free PMC article.
IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro.
Cerezo LA, Navrátilová A, Kuklová M, Prokopcová A, Baloun J, Kropáčková T, Veigl D, Popelka S, Fulín P, Ballay R, Pavelka K, Vencovský J, Šenolt L. Cerezo LA, et al. Among authors: senolt l. Arthritis Res Ther. 2024 Jul 30;26(1):146. doi: 10.1186/s13075-024-03372-z. Arthritis Res Ther. 2024. PMID: 39080724 Free PMC article.
Response to secukinumab on synovitis using Power Doppler ultrasound in psoriatic arthritis: 12-week results from a phase III study, ULTIMATE.
D'Agostino MA, Schett G, López-Rdz A, Šenolt L, Fazekas K, Burgos-Vargas R, Maldonado-Cocco J, Naredo E, Carron P, Duggan AM, Goyanka P, Boers M, Gaillez C. D'Agostino MA, et al. Among authors: senolt l. Rheumatology (Oxford). 2022 May 5;61(5):1867-1876. doi: 10.1093/rheumatology/keab628. Rheumatology (Oxford). 2022. PMID: 34528079 Free PMC article. Clinical Trial.
Decrease in serum interleukin-21 levels is associated with disease activity improvement in patients with recent-onset rheumatoid arthritis.
Sglunda O, Mann HF, Hulejová H, Pecha O, Pleštilová L, RůŽičková O, Fojtíková M, Sléglová O, Forejtová S, Pavelka K, Vencovský J, Senolt L. Sglunda O, et al. Among authors: senolt l. Physiol Res. 2014;63(4):475-81. doi: 10.33549/physiolres.932701. Epub 2014 Apr 3. Physiol Res. 2014. PMID: 24702489 Free article.
151 results