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Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo.
Neurobiol Dis. 2020 Dec;146:105078. doi: 10.1016/j.nbd.2020.105078. Epub 2020 Sep 12.
Neurobiol Dis. 2020.
PMID: 32927062
Free PMC article.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ.
Mann JR, et al. Among authors: pyles nj.
Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27.
Neuron. 2019.
PMID: 30826182
Free PMC article.
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The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.
d'Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, Ling K, Kong L, Ward AJ, Rubin LL, Rigo F, Bennett CF, Sumner CJ.
d'Ydewalle C, et al. Among authors: pyles nj.
Neuron. 2017 Jan 4;93(1):66-79. doi: 10.1016/j.neuron.2016.11.033. Epub 2016 Dec 22.
Neuron. 2017.
PMID: 28017471
Free PMC article.
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Astrocytes influence the severity of spinal muscular atrophy.
Rindt H, Feng Z, Mazzasette C, Glascock JJ, Valdivia D, Pyles N, Crawford TO, Swoboda KJ, Patitucci TN, Ebert AD, Sumner CJ, Ko CP, Lorson CL.
Rindt H, et al.
Hum Mol Genet. 2015 Jul 15;24(14):4094-102. doi: 10.1093/hmg/ddv148. Epub 2015 Apr 24.
Hum Mol Genet. 2015.
PMID: 25911676
Free PMC article.
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