Keefer C - Search Results

1

Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes.

Keefer C, Chang G, Carlo A, Novak JJ, Banker M, Carey J, Cianfrogna J, Eng H, Jagla C, Johnson N, Jones R, Jordan S, Lazzaro S, Liu J, Scott Obach R, Riccardi K, Tess D, Umland J, Racich J, Varma M, Visswanathan R, Di L. Keefer C, et al. Eur J Pharm Sci. 2020 Dec 1;155:105541. doi: 10.1016/j.ejps.2020.105541. Epub 2020 Sep 12. Eur J Pharm Sci. 2020. PMID: 32927071

2

Extraction of tacit knowledge from large ADME data sets via pairwise analysis.

Keefer CE, Chang G, Kauffman GW. Keefer CE, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3739-49. doi: 10.1016/j.bmc.2011.05.003. Epub 2011 May 6. Bioorg Med Chem. 2011. PMID: 21616672

3

Systematic and pairwise analysis of the effects of aromatic halogenation and trifluoromethyl substitution on human liver microsomal clearance.

Sun H, Keefer CE, Scott DO. Sun H, et al. Drug Metab Lett. 2011 Dec;5(4):232-42. doi: 10.2174/187231211798472575. Drug Metab Lett. 2011. PMID: 21916842

4

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Among authors: keefer c. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

5

A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.

Chang G, Huard K, Kauffman GW, Stepan AF, Keefer CE. Chang G, et al. Bioorg Med Chem. 2017 Jan 1;25(1):381-388. doi: 10.1016/j.bmc.2016.11.004. Epub 2016 Nov 2. Bioorg Med Chem. 2017. PMID: 27840138

6

The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction.

Keefer CE, Chang G. Keefer CE, et al. Medchemcomm. 2017 Oct 11;8(11):2067-2078. doi: 10.1039/c7md00465f. eCollection 2017 Nov 1. Medchemcomm. 2017. PMID: 30108724 Free PMC article.

7

In-Silico Extraction of Design Ideas Using MMPA-by-QSAR and its Application on ADME Endpoints.

Koutsoukas A, Chang G, Keefer CE. Koutsoukas A, et al. J Chem Inf Model. 2019 Jan 28;59(1):477-485. doi: 10.1021/acs.jcim.8b00520. Epub 2018 Dec 12. J Chem Inf Model. 2019. PMID: 30497262

8

Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets.

Winiwarter S, Chang G, Desai P, Menzel K, Faller B, Arimoto R, Keefer C, Broccatell F. Winiwarter S, et al. Among authors: keefer c. Mol Pharm. 2019 Sep 3;16(9):4077-4085. doi: 10.1021/acs.molpharmaceut.9b00525. Epub 2019 Aug 8. Mol Pharm. 2019. PMID: 31348668

9

Evaluation of Fraction Unbound Across 7 Tissues of 5 Species.

Ryu S, Tess D, Chang G, Keefer C, Burchett W, Steeno GS, Novak JJ, Patel R, Atkinson K, Riccardi K, Di L. Ryu S, et al. Among authors: keefer c. J Pharm Sci. 2020 Feb;109(2):1178-1190. doi: 10.1016/j.xphs.2019.10.060. Epub 2019 Nov 5. J Pharm Sci. 2020. PMID: 31704191

10

Structural attributes influencing unbound tissue distribution.

Orozco CC, Atkinson K, Ryu S, Chang G, Keefer C, Lin J, Riccardi K, Mongillo RK, Tess D, Filipski KJ, Kalgutkar AS, Litchfield J, Scott D, Di L. Orozco CC, et al. Among authors: keefer c. Eur J Med Chem. 2020 Jan 1;185:111813. doi: 10.1016/j.ejmech.2019.111813. Epub 2019 Oct 28. Eur J Med Chem. 2020. PMID: 31732255

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