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Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
Aggarwal RK, Luchtel RA, Machha V, Tischer A, Zou Y, Pradhan K, Ashai N, Ramachandra N, Albanese JM, Yang JI, Wang X, Aluri S, Gordon S, Aboumohamed A, Gartrell BA, Hafizi S, Pullman J, Shenoy N. Aggarwal RK, et al. Among authors: shenoy n. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2106947118. doi: 10.1073/pnas.2106947118. Proc Natl Acad Sci U S A. 2021. PMID: 34551979 Free PMC article.
Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.
Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K. Bhagat TD, et al. Among authors: shenoy n. J Biol Chem. 2017 Jan 20;292(3):837-846. doi: 10.1074/jbc.M116.745208. Epub 2016 Dec 1. J Biol Chem. 2017. PMID: 27909050 Free PMC article.
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
Luchtel RA, Bhagat T, Pradhan K, Jacobs WR Jr, Levine M, Verma A, Shenoy N. Luchtel RA, et al. Among authors: shenoy n. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1666-1677. doi: 10.1073/pnas.1908158117. Epub 2020 Jan 7. Proc Natl Acad Sci U S A. 2020. PMID: 31911474 Free PMC article.
Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.
Shenoy N, Bhagat TD, Cheville J, Lohse C, Bhattacharyya S, Tischer A, Machha V, Gordon-Mitchell S, Choudhary G, Wong LF, Gross L, Ressigue E, Leibovich B, Boorjian SA, Steidl U, Wu X, Pradhan K, Gartrell B, Agarwal B, Pagliaro L, Suzuki M, Greally JM, Rakheja D, Thompson RH, Susztak K, Witzig T, Zou Y, Verma A. Shenoy N, et al. J Clin Invest. 2019 Mar 4;129(4):1612-1625. doi: 10.1172/JCI98747. eCollection 2019 Mar 4. J Clin Invest. 2019. PMID: 30702441 Free PMC article.
158 results