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Page 1
The cytotoxic potential of cationic triangulenes against tumour cells.
Leung E, Pilkington LI, Naiya MM, Barker D, Zafar A, Eurtivong C, Reynisson J. Leung E, et al. Among authors: zafar a. Medchemcomm. 2019 Aug 21;10(11):1881-1891. doi: 10.1039/c9md00305c. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32952994 Free PMC article.
Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.
Leung E, Patel J, Hollywood JA, Zafar A, Tomek P, Barker D, Pilkington LI, van Rensburg M, Langley RJ, Helsby NA, Squire CJ, Baguley BC, Denny WA, Reynisson J, Leung IKH. Leung E, et al. Among authors: zafar a. Oncol Ther. 2021 Dec;9(2):541-556. doi: 10.1007/s40487-021-00158-0. Epub 2021 Jun 23. Oncol Ther. 2021. PMID: 34159519 Free PMC article.
Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O. Zakharova O, et al. Among authors: zafar a. Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24. Bioorg Med Chem. 2018. PMID: 30076000
A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor.
Hanif M, Arshad J, Astin JW, Rana Z, Zafar A, Movassaghi S, Leung E, Patel K, Söhnel T, Reynisson J, Sarojini V, Rosengren RJ, Jamieson SMF, Hartinger CG. Hanif M, et al. Among authors: zafar a. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14609-14614. doi: 10.1002/anie.202005758. Epub 2020 Jun 17. Angew Chem Int Ed Engl. 2020. PMID: 32431061
Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands.
Łomzik M, Hanif M, Budniok A, Błauż A, Makal A, Tchoń DM, Leśniewska B, Tong KKH, Movassaghi S, Söhnel T, Jamieson SMF, Zafar A, Reynisson J, Rychlik B, Hartinger CG, Plażuk D. Łomzik M, et al. Among authors: zafar a. Inorg Chem. 2020 Oct 19;59(20):14879-14890. doi: 10.1021/acs.inorgchem.0c00957. Epub 2020 Oct 1. Inorg Chem. 2020. PMID: 33003697 Free PMC article.
Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Among authors: zafar a. Eur J Med Chem. 2019 Jan 1;161:581-593. doi: 10.1016/j.ejmech.2018.10.055. Epub 2018 Oct 28. Eur J Med Chem. 2019. PMID: 30396105
1,141 results