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The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response.
Senent Y, Remírez A, Repáraz D, Llopiz D, Celias DP, Sainz C, Entrialgo-Cadierno R, Suarez L, Rouzaut A, Alignani D, Tavira B, Lambris JD, Woodruff TM, de Andrea CE, Ruffell B, Sarobe P, Ajona D, Pio R. Senent Y, et al. Among authors: ruffell b. Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0250. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39666368
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity.
Hänggi K, Li J, Gangadharan A, Liu X, Celias DP, Osunmakinde O, Keske A, Davis J, Ahmad F, Giron A, Anadon CM, Gardner A, DeNardo DG, Shaw TI, Beg AA, Yu X, Ruffell B. Hänggi K, et al. Among authors: ruffell b. Cancer Cell. 2024 Dec 9;42(12):2015-2031.e11. doi: 10.1016/j.ccell.2024.10.014. Epub 2024 Nov 21. Cancer Cell. 2024. PMID: 39577420
Macrophage-mediated myelin recycling fuels brain cancer malignancy.
Kloosterman DJ, Erbani J, Boon M, Farber M, Handgraaf SM, Ando-Kuri M, Sánchez-López E, Fontein B, Mertz M, Nieuwland M, Liu NQ, Forn-Cuni G, van der Wel NN, Grootemaat AE, Reinalda L, van Kasteren SI, de Wit E, Ruffell B, Snaar-Jagalska E, Petrecca K, Brandsma D, Kros A, Giera M, Akkari L. Kloosterman DJ, et al. Among authors: ruffell b. Cell. 2024 Sep 19;187(19):5336-5356.e30. doi: 10.1016/j.cell.2024.07.030. Epub 2024 Aug 12. Cell. 2024. PMID: 39137777 Free PMC article.
Rapid Autopsy to Define Dendritic Cell Spatial Distribution and T Cell Association in Lung Adenocarcinoma.
Ozakinci H, Song X, Nazario GS, Lila T, Chen B, Simpson T, Nguyen JV, Moran Segura CM, Thompson ZJ, Thapa R, Rose TA, Haura EB, Pellini B, Yu X, Ruffell BH, Chen DT, Boyle TA, Beg AA. Ozakinci H, et al. Among authors: ruffell bh. J Immunol. 2024 Oct 1;213(7):1033-1041. doi: 10.4049/jimmunol.2400234. J Immunol. 2024. PMID: 39120462 Free PMC article.
Cell death, therapeutics, and the immune response in cancer.
Hänggi K, Ruffell B. Hänggi K, et al. Among authors: ruffell b. Trends Cancer. 2023 May;9(5):381-396. doi: 10.1016/j.trecan.2023.02.001. Epub 2023 Feb 24. Trends Cancer. 2023. PMID: 36841748 Free PMC article. Review.
64 results