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Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Garcia-Reitboeck P, Phillips A, Piers TM, Villegas-Llerena C, Butler M, Mallach A, Rodrigues C, Arber CE, Heslegrave A, Zetterberg H, Neumann H, Neame S, Houlden H, Hardy J, Pocock JM. Garcia-Reitboeck P, et al. Among authors: mallach a. Cell Rep. 2018 Aug 28;24(9):2300-2311. doi: 10.1016/j.celrep.2018.07.094. Cell Rep. 2018. PMID: 30157425 Free PMC article.
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Popescu AS, Butler CA, Allendorf DH, Piers TM, Mallach A, Roewe J, Reinhardt P, Cinti A, Redaelli L, Boudesco C, Pradier L, Pocock JM, Thornton P, Brown GC. Popescu AS, et al. Among authors: mallach a. Glia. 2023 Apr;71(4):974-990. doi: 10.1002/glia.24318. Epub 2022 Dec 8. Glia. 2023. PMID: 36480007 Free PMC article.
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Nazish I, Mamais A, Mallach A, Bettencourt C, Kaganovich A, Warner T, Hardy J, Lewis PA, Pocock J, Cookson MR, Bandopadhyay R. Nazish I, et al. Among authors: mallach a. bioRxiv [Preprint]. 2023 Sep 14:2023.09.14.557532. doi: 10.1101/2023.09.14.557532. bioRxiv. 2023. Update in: Cells. 2023 Dec 26;13(1):53. doi: 10.3390/cells13010053 PMID: 37745519 Free PMC article. Updated. Preprint.
14 results