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Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.
Aliotta F, Nasso R, Rullo R, Arcucci A, Avagliano A, Simonetti M, Sanità G, Masullo M, Lavecchia A, Ruocco MR, Vendittis E. Aliotta F, et al. Among authors: lavecchia a. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1866-1878. doi: 10.1080/14756366.2020.1819257. J Enzyme Inhib Med Chem. 2020. PMID: 32990107 Free PMC article.
CDC25 phosphatase inhibitors: an update.
Lavecchia A, Di Giovanni C, Novellino E. Lavecchia A, et al. Mini Rev Med Chem. 2012 Jan;12(1):62-73. doi: 10.2174/138955712798868940. Mini Rev Med Chem. 2012. PMID: 22070688 Review.
Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.
Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L. Petrelli R, et al. Among authors: lavecchia a. J Med Chem. 2017 May 25;60(10):4327-4341. doi: 10.1021/acs.jmedchem.7b00291. Epub 2017 May 5. J Med Chem. 2017. PMID: 28447789 Free PMC article.
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.
Cerchia C, Nasso R, Mori M, Villa S, Gelain A, Capasso A, Aliotta F, Simonetti M, Rullo R, Masullo M, De Vendittis E, Ruocco MR, Lavecchia A. Cerchia C, et al. Among authors: lavecchia a. J Med Chem. 2019 Aug 8;62(15):7089-7110. doi: 10.1021/acs.jmedchem.9b00632. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31294975
208 results