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The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Arena C, Gado F, Di Cesare Mannelli L, Cervetto C, Carpi S, Reynoso-Moreno I, Polini B, Vallini E, Chicca S, Lucarini E, Bertini S, D'Andrea F, Digiacomo M, Poli G, Tuccinardi T, Macchia M, Gertsch J, Marcoli M, Nieri P, Ghelardini C, Chicca A, Manera C. Arena C, et al. Among authors: tuccinardi t. Eur J Med Chem. 2020 Dec 15;208:112858. doi: 10.1016/j.ejmech.2020.112858. Epub 2020 Sep 29. Eur J Med Chem. 2020. PMID: 33002735
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.
Manera C, Betti L, Cavallini T, Giannaccini G, Martinelli A, Ortore G, Saccomanni G, Trincavelli L, Tuccinardi T, Ferrarini PL. Manera C, et al. Among authors: tuccinardi t. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. doi: 10.1016/j.bmcl.2005.06.064. Bioorg Med Chem Lett. 2005. PMID: 16099648
Adenosine receptor modelling. A1/A2a selectivity.
Tuccinardi T, Ortore G, Manera C, Saccomanni G, Martinelli A. Tuccinardi T, et al. Eur J Med Chem. 2006 Mar;41(3):321-9. doi: 10.1016/j.ejmech.2005.09.011. Epub 2006 Jan 19. Eur J Med Chem. 2006. PMID: 16427161
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.
Manera C, Cascio MG, Benetti V, Allarà M, Tuccinardi T, Martinelli A, Saccomanni G, Vivoli E, Ghelardini C, Di Marzo V, Ferrarini PL. Manera C, et al. Among authors: tuccinardi t. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. doi: 10.1016/j.bmcl.2007.09.089. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17942307
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.
Minutolo F, Bellini R, Bertini S, Carboni I, Lapucci A, Pistolesi L, Prota G, Rapposelli S, Solati F, Tuccinardi T, Martinelli A, Stossi F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Macchia M. Minutolo F, et al. Among authors: tuccinardi t. J Med Chem. 2008 Mar 13;51(5):1344-51. doi: 10.1021/jm701396g. Epub 2008 Feb 13. J Med Chem. 2008. PMID: 18269232
223 results