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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D. Zhang X, et al. Among authors: reedtz runge s. Mol Cell. 2020 Nov 5;80(3):485-500.e7. doi: 10.1016/j.molcel.2020.09.020. Epub 2020 Oct 6. Mol Cell. 2020. PMID: 33027691 Free article.
Structural basis of Gs and Gi recognition by the human glucagon receptor.
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B. Qiao A, et al. Among authors: reedtz runge s. Science. 2020 Mar 20;367(6484):1346-1352. doi: 10.1126/science.aaz5346. Science. 2020. PMID: 32193322
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. Lau J, et al. J Med Chem. 2015 Sep 24;58(18):7370-80. doi: 10.1021/acs.jmedchem.5b00726. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26308095
Full-length human GLP-1 receptor structure without orthosteric ligands.
Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Wu F, et al. Among authors: reedtz runge s. Nat Commun. 2020 Mar 9;11(1):1272. doi: 10.1038/s41467-020-14934-5. Nat Commun. 2020. PMID: 32152292 Free PMC article.
25 results