Qi J - Search Results

1

Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.

Xu G, Gaul MD, Liu Z, DesJarlais RL, Qi J, Wang W, Krosky D, Petrounia I, Milligan CM, Hermans A, Lu HR, Huang DZ, Xu JZ, Spurlino JC. Xu G, et al. Among authors: qi j. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127602. doi: 10.1016/j.bmcl.2020.127602. Epub 2020 Oct 7. Bioorg Med Chem Lett. 2020. PMID: 33038544

2

Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.

Luci DK, Ghosh S, Smith CE, Qi J, Wang Y, Haertlein B, Parry TJ, Li J, Almond HR Jr, Minor LK, Damiano BP, Kinney WA, Maryanoff BE, Lawson EC. Luci DK, et al. Among authors: qi j. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6489-92. doi: 10.1016/j.bmcl.2007.09.092. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933531

3

Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.

Lawson EC, Luci DK, Ghosh S, Kinney WA, Reynolds CH, Qi J, Smith CE, Wang Y, Minor LK, Haertlein BJ, Parry TJ, Damiano BP, Maryanoff BE. Lawson EC, et al. Among authors: qi j. J Med Chem. 2009 Dec 10;52(23):7432-45. doi: 10.1021/jm900683d. J Med Chem. 2009. PMID: 19731961

4

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA. Qi J, et al. J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3. J Lipid Res. 2012. PMID: 22493088 Free PMC article.

5

Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.

Qi J, Lang W, Connelly MA, Du F, Liang Y, Caldwell GW, Martin T, Hansen MK, Kuo GH, Gaul MD, Pocai A, Lee S. Qi J, et al. Anal Biochem. 2017 May 1;524:68-75. doi: 10.1016/j.ab.2016.09.017. Epub 2016 Sep 22. Anal Biochem. 2017. PMID: 27665677

6

Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors.

Qi J, Masucci JA, Lang W, Connelly MA, Caldwell GW, Petrounia I, Kirkpatrick J, Barnakov AN, Struble G, Miller R, Dzordzorine K, Kuo GH, Gaul M, Pocai A, Lee S. Qi J, et al. SLAS Discov. 2017 Apr;22(4):433-439. doi: 10.1177/2472555217690101. Epub 2017 Jan 31. SLAS Discov. 2017. PMID: 28328322 Free article.

7

Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.

Kuo GH, Gaul MD, Liang Y, Xu JZ, Du F, Hornby P, Xu G, Qi J, Wallace N, Lee S, Grant E, Murray WV, Demarest K. Kuo GH, et al. Among authors: qi j. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1182-1187. doi: 10.1016/j.bmcl.2018.02.057. Epub 2018 Mar 1. Bioorg Med Chem Lett. 2018. PMID: 29523385

8

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB₁) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.

Zhang YM, Greco MN, Macielag MJ, Teleha CA, DesJarlais RL, Tang Y, Ho G, Hou C, Chen C, Zhao S, Kauffman J, Camacho R, Qi J, Murray W, Demarest K, Leonard J. Zhang YM, et al. Among authors: qi j. J Med Chem. 2018 Nov 21;61(22):10276-10298. doi: 10.1021/acs.jmedchem.8b01467. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30339387

9

GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action.

Lee SP, Qi J, Xu G, Rankin MM, Littrell J, Xu JZ, Bakaj I, Pocai A. Lee SP, et al. Among authors: qi j. Front Endocrinol (Lausanne). 2021 May 14;12:652628. doi: 10.3389/fendo.2021.652628. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34054727 Free PMC article.

10

Pan AMPK Activation Protects Tubules in Rat Ischemic Acute Kidney Injury.

Frikke-Schmidt H, Albarazanji K, Qi J, Frederick D, Steffen J, Kalyana-Sundaram S, Meng R, Devine ZH, Chen T, Li Q, Du F, Ho G, Liu J, Riley R, Gonzalez-Villalobos RA, Camacho RC, Nawrocki AR, Pryor M, Lee M, Wong V, Matico R, Diaz E, Krosky D, Wall M, Gao E, Shah AA, Leonard J, Erion M, Pocai A, Player MR. Frikke-Schmidt H, et al. Among authors: qi j. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2024-002120. doi: 10.1124/jpet.124.002120. Online ahead of print. J Pharmacol Exp Ther. 2024. PMID: 38849142 Free article.

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