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Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism.
Moore SC, Penrice-Randal R, Alruwaili M, Randle N, Armstrong S, Hartley C, Haldenby S, Dong X, Alrezaihi A, Almsaud M, Bentley E, Clark J, García-Dorival I, Gilmore P, Han X, Jones B, Luu L, Sharma P, Shawli G, Sun Y, Zhao Q, Pullan ST, Carter DP, Bewley K, Dunning J, Zhou EM, Solomon T, Beadsworth M, Cruise J, Crook DW, Matthews DA, Davidson AD, Mahmood Z, Aljabr W, Druce J, Vipond R, Ng L, Renia L, Openshaw PJM, Baillie JK, Carroll MW, Stewart J, Darby A, Semple M, Turtle L, Hiscox JA. Moore SC, et al. Among authors: randle n. Viruses. 2020 Oct 14;12(10):1164. doi: 10.3390/v12101164. Viruses. 2020. PMID: 33066701 Free PMC article.
Developing a 3D intestinal epithelium model for livestock species.
Derricott H, Luu L, Fong WY, Hartley CS, Johnston LJ, Armstrong SD, Randle N, Duckworth CA, Campbell BJ, Wastling JM, Coombes JL. Derricott H, et al. Among authors: randle n. Cell Tissue Res. 2019 Feb;375(2):409-424. doi: 10.1007/s00441-018-2924-9. Epub 2018 Sep 26. Cell Tissue Res. 2019. PMID: 30259138 Free PMC article.
Tissue-Specific Immunopathology in Fatal COVID-19.
Dorward DA, Russell CD, Um IH, Elshani M, Armstrong SD, Penrice-Randal R, Millar T, Lerpiniere CEB, Tagliavini G, Hartley CS, Randle NP, Gachanja NN, Potey PMD, Dong X, Anderson AM, Campbell VL, Duguid AJ, Al Qsous W, BouHaidar R, Baillie JK, Dhaliwal K, Wallace WA, Bellamy COC, Prost S, Smith C, Hiscox JA, Harrison DJ, Lucas CD. Dorward DA, et al. Among authors: randle np. Am J Respir Crit Care Med. 2021 Jan 15;203(2):192-201. doi: 10.1164/rccm.202008-3265OC. Am J Respir Crit Care Med. 2021. PMID: 33217246 Free PMC article.
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.
Zhou J, Peacock TP, Brown JC, Goldhill DH, Elrefaey AME, Penrice-Randal R, Cowton VM, De Lorenzo G, Furnon W, Harvey WT, Kugathasan R, Frise R, Baillon L, Lassaunière R, Thakur N, Gallo G, Goldswain H, Donovan-Banfield I, Dong X, Randle NP, Sweeney F, Glynn MC, Quantrill JL, McKay PF, Patel AH, Palmarini M, Hiscox JA, Bailey D, Barclay WS. Zhou J, et al. Among authors: randle np. Cell Rep. 2022 Feb 8;38(6):110344. doi: 10.1016/j.celrep.2022.110344. Epub 2022 Jan 19. Cell Rep. 2022. PMID: 35093235 Free PMC article.
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages.
Prince T, Dong X, Penrice-Randal R, Randle N, Hartley C, Goldswain H, Jones B, Semple MG, Baillie JK, Openshaw PJM, Turtle L, Hughes GL, Anderson ER, Patterson EI, Druce J, Screaton G, Carroll MW, Stewart JP, Hiscox JA. Prince T, et al. Among authors: randle n. mSphere. 2022 Jun 29;7(3):e0091321. doi: 10.1128/msphere.00913-21. Epub 2022 May 2. mSphere. 2022. PMID: 35491827 Free PMC article.
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers.
Dong X, Penrice-Randal R, Goldswain H, Prince T, Randle N, Donovan-Banfield I, Salguero FJ, Tree J, Vamos E, Nelson C, Clark J, Ryan Y, Stewart JP, Semple MG, Baillie JK, Openshaw PJM, Turtle L, Matthews DA, Carroll MW, Darby AC, Hiscox JA. Dong X, et al. Among authors: randle n. Gigascience. 2022 May 26;11:giac045. doi: 10.1093/gigascience/giac045. Gigascience. 2022. PMID: 35639883 Free PMC article.
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain H, Dong X, Penrice-Randal R, Alruwaili M, Shawli GT, Prince T, Williamson MK, Raghwani J, Randle N, Jones B, Donovan-Banfield I, Salguero FJ, Tree JA, Hall Y, Hartley C, Erdmann M, Bazire J, Jearanaiwitayakul T, Semple MG, Openshaw PJM, Baillie JK; ISARIC4C Investigators; Emmett SR, Digard P, Matthews DA, Turtle L, Darby AC, Davidson AD, Carroll MW, Hiscox JA. Goldswain H, et al. Among authors: randle n. Genome Biol. 2023 Mar 13;24(1):47. doi: 10.1186/s13059-023-02881-5. Genome Biol. 2023. PMID: 36915185 Free PMC article.
24 results