Li Y - Search Results

1

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay.

Lin W, Li Y, Min J, Liu J, Yang L, Lee RE, Chen T. Lin W, et al. Among authors: li y. Bioconjug Chem. 2020 Nov 18;31(11):2564-2575. doi: 10.1021/acs.bioconjchem.0c00507. Epub 2020 Oct 18. Bioconjug Chem. 2020. PMID: 33070611 Free PMC article.

2

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Chai SC, Lin W, Li Y, Chen T. Chai SC, et al. Among authors: li y. Drug Discov Today. 2019 Mar;24(3):906-915. doi: 10.1016/j.drudis.2019.01.021. Epub 2019 Feb 4. Drug Discov Today. 2019. PMID: 30731240 Free PMC article. Review.

3

CITCO Directly Binds to and Activates Human Pregnane X Receptor.

Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T. Lin W, et al. Among authors: li y. Mol Pharmacol. 2020 Mar;97(3):180-190. doi: 10.1124/mol.119.118513. Epub 2019 Dec 27. Mol Pharmacol. 2020. PMID: 31882411 Free PMC article.

4

Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay.

Lin W, Li Y, Yang L, Chen T. Lin W, et al. Among authors: li y. ACS Omega. 2020 Dec 29;6(1):680-695. doi: 10.1021/acsomega.0c05221. eCollection 2021 Jan 12. ACS Omega. 2020. PMID: 33458521 Free PMC article.

5

Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70.

Li Y, Lin W, Wright WC, Chai SC, Wu J, Chen T. Li Y, et al. J Med Chem. 2021 Feb 11;64(3):1733-1761. doi: 10.1021/acs.jmedchem.0c02201. Epub 2021 Jan 26. J Med Chem. 2021. PMID: 33497575 Free PMC article.

6

SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.

Huber AD, Li Y, Lin W, Galbraith AN, Mishra A, Porter SN, Wu J, Florke Gee RR, Zhuang W, Pruett-Miller SM, Peng J, Chen T. Huber AD, et al. Among authors: li y. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320. doi: 10.1021/acsmedchemlett.2c00223. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978691 Free PMC article.

7

Design and Optimization of 1H-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR.

Li Y, Lin W, Chai SC, Wu J, Annu K, Chen T. Li Y, et al. J Med Chem. 2022 Dec 22;65(24):16829-16859. doi: 10.1021/acs.jmedchem.2c01640. Epub 2022 Dec 8. J Med Chem. 2022. PMID: 36480704 Free PMC article.

8

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.

Lin W, Huber AD, Poudel S, Li Y, Seetharaman J, Miller DJ, Chen T. Lin W, et al. Among authors: li y. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2217804120. doi: 10.1073/pnas.2217804120. Epub 2023 Feb 27. Proc Natl Acad Sci U S A. 2023. PMID: 36848571 Free PMC article.

9

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.

Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T. Huber AD, et al. Among authors: li y. Structure. 2023 Dec 7;31(12):1545-1555.e9. doi: 10.1016/j.str.2023.08.020. Epub 2023 Sep 19. Structure. 2023. PMID: 37729916 Free PMC article.

10

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy.

Huber AD, Jung YH, Li Y, Lin W, Wu J, Poudel S, Carrigan AG, Mishra A, High AA, Chen T. Huber AD, et al. Among authors: li y. J Med Chem. 2024 Oct 24;67(20):18549-18575. doi: 10.1021/acs.jmedchem.4c01926. Epub 2024 Oct 15. J Med Chem. 2024. PMID: 39405362

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