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Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome.
Paige SL, Galdos FX, Lee S, Chin ET, Ranjbarvaziri S, Feyen DAM, Darsha AK, Xu S, Ryan JA, Beck AL, Qureshi MY, Miao Y, Gu M, Bernstein D, Nelson TJ, Mercola M, Rabinovitch M, Ashley EA, Parikh VN, Wu SM. Paige SL, et al. Among authors: mercola m. Circulation. 2020 Oct 20;142(16):1605-1608. doi: 10.1161/CIRCULATIONAHA.119.045317. Epub 2020 Oct 19. Circulation. 2020. PMID: 33074758 Free PMC article. No abstract available.
CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes.
Chirikian O, Goodyer WR, Dzilic E, Serpooshan V, Buikema JW, McKeithan W, Wu H, Li G, Lee S, Merk M, Galdos F, Beck A, Ribeiro AJS, Paige S, Mercola M, Wu JC, Pruitt BL, Wu SM. Chirikian O, et al. Among authors: mercola m. Sci Rep. 2021 Feb 4;11(1):3026. doi: 10.1038/s41598-021-81860-x. Sci Rep. 2021. PMID: 33542270 Free PMC article.
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. Seeger T, et al. Among authors: mercola m. Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624. Circulation. 2019. PMID: 30586709 Free PMC article.
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. Feyen DAM, et al. Among authors: mercola m. Cell Rep. 2020 Jul 21;32(3):107925. doi: 10.1016/j.celrep.2020.107925. Cell Rep. 2020. PMID: 32697997 Free PMC article.
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.
Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur Ataam J, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, Zhang Y, Dunkenberger L, Sluijter JPG, Sallam K, Asselbergs FW, Mercola M, Karakikes I. Feyen DAM, et al. Among authors: mercola m. Circulation. 2021 Aug 3;144(5):382-392. doi: 10.1161/CIRCULATIONAHA.120.049844. Epub 2021 Apr 30. Circulation. 2021. PMID: 33928785 Free PMC article.
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. Sharma A, et al. Among authors: mercola m. Sci Transl Med. 2017 Feb 15;9(377):eaaf2584. doi: 10.1126/scitranslmed.aaf2584. Sci Transl Med. 2017. PMID: 28202772 Free PMC article.
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.
McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL Jr, Kass RS, Cashman JR, Mercola M. McKeithan WL, et al. Among authors: mercola m. Cell Stem Cell. 2020 Nov 5;27(5):813-821.e6. doi: 10.1016/j.stem.2020.08.003. Epub 2020 Sep 14. Cell Stem Cell. 2020. PMID: 32931730 Free PMC article.
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I. Perea-Gil I, et al. Among authors: mercola m. Eur Heart J. 2022 Sep 21;43(36):3477-3489. doi: 10.1093/eurheartj/ehac305. Eur Heart J. 2022. PMID: 35728000 Free PMC article.
176 results