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Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
Ibrahim TS, Hawwas MM, Taher ES, Alhakamy NA, Alfaleh MA, Elagawany M, Elgendy B, Zayed GM, Mohamed MFA, Abdel-Samii ZK, Elshaier YAMM. Ibrahim TS, et al. Among authors: hawwas mm. Bioorg Chem. 2020 Dec;105:104352. doi: 10.1016/j.bioorg.2020.104352. Epub 2020 Oct 8. Bioorg Chem. 2020. PMID: 33080494
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Ibrahim TS, Hawwas MM, Malebari AM, Taher ES, Omar AM, Neamatallah T, Abdel-Samii ZK, Safo MK, Elshaier YAMM. Ibrahim TS, et al. Among authors: hawwas mm. J Enzyme Inhib Med Chem. 2021 Dec;36(1):802-818. doi: 10.1080/14756366.2021.1899168. J Enzyme Inhib Med Chem. 2021. PMID: 33730937 Free PMC article.