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Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions.
Morgan SJ, Lippman SI, Bautista GE, Harrison JJ, Harding CL, Gallagher LA, Cheng AC, Siehnel R, Ravishankar S, Usui ML, Olerud JE, Fleckman P, Wolcott RD, Manoil C, Singh PK. Morgan SJ, et al. Among authors: ravishankar s. PLoS Pathog. 2019 Mar 20;15(3):e1007511. doi: 10.1371/journal.ppat.1007511. eCollection 2019 Mar. PLoS Pathog. 2019. PMID: 30893371 Free PMC article.
Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome.
Nelson MT, Wolter DJ, Eng A, Weiss EJ, Vo AT, Brittnacher MJ, Hayden HS, Ravishankar S, Bautista G, Ratjen A, Blackledge M, McNamara S, Nay L, Majors C, Miller SI, Borenstein E, Simon RH, LiPuma JJ, Hoffman LR. Nelson MT, et al. Among authors: ravishankar s. Thorax. 2020 Sep;75(9):780-790. doi: 10.1136/thoraxjnl-2019-214187. Epub 2020 Jul 6. Thorax. 2020. PMID: 32631930 Free PMC article.
Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK. Goss CH, et al. Among authors: ravishankar s. Sci Transl Med. 2018 Sep 26;10(460):eaat7520. doi: 10.1126/scitranslmed.aat7520. Sci Transl Med. 2018. PMID: 30257953 Free PMC article. Clinical Trial.
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.
Young C, Singh M, Jackson KJL, Field MA, Peters TJ, Angioletti-Uberti S, Frenkel D, Ravishankar S, Gupta M, Wang JJ, Agapiou D, Faulks ML, Al-Eryani G, Luciani F, Gordon TP, Reed JH, Danta M, Carr A, Kelleher AD, Dore GJ, Matthews G, Brink R, Bull RA, Suan D, Goodnow CC. Young C, et al. Among authors: ravishankar s. Immunity. 2025 Jan 9:S1074-7613(24)00575-2. doi: 10.1016/j.immuni.2024.12.011. Online ahead of print. Immunity. 2025. PMID: 39818208 Free article.
Developmentally-regulated proteolysis by MdfA and ClpCP mediates metabolic differentiation during Bacillus subtilis sporulation.
Riley EP, Lyda JA, Reyes-Matte O, Sugie J, Kasu IR, Enustun E, Armbruster E, Ravishankar S, Isaacson RL, Camp AH, Lopez-Garrido J, Pogliano K. Riley EP, et al. Among authors: ravishankar s. bioRxiv [Preprint]. 2024 Nov 26:2024.11.26.625531. doi: 10.1101/2024.11.26.625531. bioRxiv. 2024. PMID: 39651166 Free PMC article. Preprint.
232 results