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Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q. Yang PB, et al. Among authors: lin t. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27412-27422. doi: 10.1073/pnas.2002997117. Epub 2020 Oct 21. Proc Natl Acad Sci U S A. 2020. PMID: 33087562 Free PMC article.
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q. Zhan YY, et al. Among authors: lin t, lin sc. Nat Chem Biol. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep 16. Nat Chem Biol. 2012. PMID: 22983157
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q. Wang WJ, et al. Among authors: lin t. Nat Chem Biol. 2014 Feb;10(2):133-40. doi: 10.1038/nchembio.1406. Epub 2013 Dec 8. Nat Chem Biol. 2014. PMID: 24316735
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q. Li L, et al. Among authors: lin t. Nat Chem Biol. 2015 May;11(5):339-46. doi: 10.1038/nchembio.1788. Epub 2015 Mar 30. Nat Chem Biol. 2015. PMID: 25822914 Free article.
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
Wu C, Zhang L, Li P, Cai Q, Peng X, Yin K, Chen X, Ren H, Zhong S, Weng Y, Guan Y, Chen S, Wu J, Li J, Lin T. Wu C, et al. Among authors: lin t. Biochim Biophys Acta. 2016 Jun;1860(6):1299-307. doi: 10.1016/j.bbagen.2016.03.017. Epub 2016 Mar 15. Biochim Biophys Acta. 2016. PMID: 26987809
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Li P, Wu S, Xiao T, Li Y, Su Z, Wei W, Hao F, Hu G, Lin F, Chen X, Gu Z, Lin T, He H, Li J, Chen S. Li P, et al. Among authors: lin f, lin t. Bioorg Med Chem. 2020 Jun 15;28(12):115551. doi: 10.1016/j.bmc.2020.115551. Epub 2020 May 8. Bioorg Med Chem. 2020. PMID: 32503695
The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency.
Chen X, Wu C, Liang W, Shen J, Zhuo Z, Hu L, Ruan L, Zhang P, Xu L, Li C, Lin S, Lan J, Ren H, Yao H, Zhao T, Gao B, Lin T, Huang H, Li C. Chen X, et al. Among authors: lin t, lin s. Evid Based Complement Alternat Med. 2020 Dec 9;2020:8568353. doi: 10.1155/2020/8568353. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 33376499 Free PMC article.
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