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The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.
Vaughan RM, Kupai A, Foley CA, Sagum CA, Tibben BM, Eden HE, Tiedemann RL, Berryhill CA, Patel V, Shaw KM, Krajewski K, Strahl BD, Bedford MT, Frye SV, Dickson BM, Rothbart SB. Vaughan RM, et al. Among authors: rothbart sb. Epigenetics Chromatin. 2020 Oct 23;13(1):44. doi: 10.1186/s13072-020-00366-4. Epigenetics Chromatin. 2020. PMID: 33097091 Free PMC article.
Peptide microarrays to interrogate the "histone code".
Rothbart SB, Krajewski K, Strahl BD, Fuchs SM. Rothbart SB, et al. Methods Enzymol. 2012;512:107-35. doi: 10.1016/B978-0-12-391940-3.00006-8. Methods Enzymol. 2012. PMID: 22910205 Free PMC article.
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.
Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Rothbart SB, et al. Nat Struct Mol Biol. 2012 Nov;19(11):1155-60. doi: 10.1038/nsmb.2391. Epub 2012 Sep 30. Nat Struct Mol Biol. 2012. PMID: 23022729 Free PMC article.
Molecular basis for chromatin binding and regulation of MLL5.
Ali M, Rincón-Arano H, Zhao W, Rothbart SB, Tong Q, Parkhurst SM, Strahl BD, Deng LW, Groudine M, Kutateladze TG. Ali M, et al. Among authors: rothbart sb. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11296-301. doi: 10.1073/pnas.1310156110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798402 Free PMC article.
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, Groudine M, Li W, Shi X, Kutateladze TG. Klein BJ, et al. Among authors: rothbart sb. Cell Rep. 2014 Jan 30;6(2):325-35. doi: 10.1016/j.celrep.2013.12.021. Epub 2014 Jan 9. Cell Rep. 2014. PMID: 24412361 Free PMC article.
78 results