Jinek M - Search Results

1

Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a.

Saha A, Arantes PR, Hsu RV, Narkhede YB, Jinek M, Palermo G. Saha A, et al. Among authors: jinek m. J Chem Inf Model. 2020 Dec 28;60(12):6427-6437. doi: 10.1021/acs.jcim.0c00929. Epub 2020 Oct 27. J Chem Inf Model. 2020. PMID: 33107304 Free PMC article.

2

PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.

Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez T, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Koseki S, et al. Among authors: jinek m. Res Sq [Preprint]. 2023 Mar 7:rs.3.rs-2625838. doi: 10.21203/rs.3.rs-2625838/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y PMID: 36945419 Free PMC article. Updated. Preprint.

3

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA. Sternberg SH, et al. Among authors: jinek m. Nature. 2014 Mar 6;507(7490):62-7. doi: 10.1038/nature13011. Epub 2014 Jan 29. Nature. 2014. PMID: 24476820 Free PMC article.

4

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA. Palermo G, et al. Among authors: jinek m. ACS Cent Sci. 2016 Oct 26;2(10):756-763. doi: 10.1021/acscentsci.6b00218. Epub 2016 Sep 9. ACS Cent Sci. 2016. PMID: 27800559 Free PMC article.

5

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

Swarts DC, van der Oost J, Jinek M. Swarts DC, et al. Among authors: jinek m. Mol Cell. 2017 Apr 20;66(2):221-233.e4. doi: 10.1016/j.molcel.2017.03.016. Mol Cell. 2017. PMID: 28431230 Free PMC article.

6

CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.

Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA. Palermo G, et al. Among authors: jinek m. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7260-7265. doi: 10.1073/pnas.1707645114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652374 Free PMC article.

7

Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.

Palermo G, Ricci CG, Fernando A, Basak R, Jinek M, Rivalta I, Batista VS, McCammon JA. Palermo G, et al. Among authors: jinek m. J Am Chem Soc. 2017 Nov 15;139(45):16028-16031. doi: 10.1021/jacs.7b05313. Epub 2017 Aug 7. J Am Chem Soc. 2017. PMID: 28764328 Free PMC article.

8

Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases.

Garcia-Doval C, Jinek M. Garcia-Doval C, et al. Among authors: jinek m. Curr Opin Struct Biol. 2017 Dec;47:157-166. doi: 10.1016/j.sbi.2017.10.015. Epub 2017 Nov 3. Curr Opin Struct Biol. 2017. PMID: 29107822 Review.

9

Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain.

Palermo G, Chen JS, Ricci CG, Rivalta I, Jinek M, Batista VS, Doudna JA, McCammon JA. Palermo G, et al. Among authors: jinek m. Q Rev Biophys. 2018;51:e91. doi: 10.1017/S0033583518000070. Epub 2018 Aug 3. Q Rev Biophys. 2018. PMID: 30555184 Free PMC article.

10

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.

Swarts DC, Jinek M. Swarts DC, et al. Among authors: jinek m. Mol Cell. 2019 Feb 7;73(3):589-600.e4. doi: 10.1016/j.molcel.2018.11.021. Epub 2019 Jan 10. Mol Cell. 2019. PMID: 30639240 Free PMC article.

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