Gao ZB - Search Results

1

Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors.

Xiang HY, Wang X, Chen YH, Zhang X, Tan C, Wang Y, Su Y, Gao ZW, Chen XY, Xiong B, Gao ZB, Chen Y, Ding J, Meng LH, Yang CH. Xiang HY, et al. Among authors: gao zw, gao zb. Eur J Med Chem. 2021 Jan 1;209:112913. doi: 10.1016/j.ejmech.2020.112913. Epub 2020 Oct 21. Eur J Med Chem. 2021. PMID: 33109399

2

Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.

Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Liu H, et al. Among authors: gao zb. J Med Chem. 2007 Jan 11;50(1):83-93. doi: 10.1021/jm060414o. J Med Chem. 2007. PMID: 17201412

3

Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Ji X, Xia C, Wang J, Su M, Zhang L, Dong T, Li Z, Wan X, Li J, Li J, Zhao L, Gao Z, Jiang H, Liu H. Ji X, et al. Eur J Med Chem. 2014 Oct 30;86:242-56. doi: 10.1016/j.ejmech.2014.08.059. Epub 2014 Aug 19. Eur J Med Chem. 2014. PMID: 25164763

4

Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.

Sun H, Shi M, Zhang W, Zheng YM, Xu YZ, Shi JJ, Liu T, Gunosewoyo H, Pang T, Gao ZB, Yang F, Tang J, Yu LF. Sun H, et al. Among authors: gao zb. J Med Chem. 2016 Jul 14;59(13):6329-43. doi: 10.1021/acs.jmedchem.6b00571. Epub 2016 Jun 30. J Med Chem. 2016. PMID: 27309376

5

The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7.

Zhang WM, Yang T, Pan XY, Liu XL, Lin HX, Gao ZB, Yang CG, Cui YM. Zhang WM, et al. Among authors: gao zb. Eur J Med Chem. 2017 Feb 15;127:917-927. doi: 10.1016/j.ejmech.2016.11.002. Epub 2016 Nov 3. Eur J Med Chem. 2017. PMID: 27837995

6

The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid.

Zhang WM, Yao Y, Yang T, Wang XY, Zhu ZY, Xu WT, Lin HX, Gao ZB, Zhou H, Yang CG, Cui YM. Zhang WM, et al. Among authors: gao zb. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1943-1948. doi: 10.1016/j.bmcl.2018.03.062. Epub 2018 Mar 23. Bioorg Med Chem Lett. 2018. PMID: 29650291

7

Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors.

Xiang HY, Chen JY, Huan XJ, Chen Y, Gao ZB, Ding J, Miao ZH, Yang CH. Xiang HY, et al. Among authors: gao zb. Bioorg Med Chem Lett. 2021 Jan 1;31:127710. doi: 10.1016/j.bmcl.2020.127710. Epub 2020 Nov 24. Bioorg Med Chem Lett. 2021. PMID: 33246105

8

Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.

Zhang YM, Xu HY, Hu HN, Tian FY, Chen F, Liu HN, Zhan L, Pi XP, Liu J, Gao ZB, Nan FJ. Zhang YM, et al. Among authors: gao zb. J Med Chem. 2021 May 13;64(9):5816-5837. doi: 10.1021/acs.jmedchem.0c02252. Epub 2021 Apr 30. J Med Chem. 2021. PMID: 33929863

9

Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates.

Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ. Wang Y, et al. Among authors: gao zb. Acta Pharmacol Sin. 2022 Apr;43(4):781-787. doi: 10.1038/s41401-021-00732-2. Epub 2021 Jul 22. Acta Pharmacol Sin. 2022. PMID: 34294887 Free PMC article.

10

Corrigendum to "Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors" [Bioorg. Med. Chem. Lett. 31 (2021) 127710].

Xiang HY, Chen JY, Huan XJ, Chen Y, Gao ZB, Ding J, Miao ZH, Yang CH. Xiang HY, et al. Among authors: gao zb. Bioorg Med Chem Lett. 2022 Jan 15;56:128501. doi: 10.1016/j.bmcl.2021.128501. Epub 2021 Dec 12. Bioorg Med Chem Lett. 2022. PMID: 34911648 No abstract available.

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