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Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Peng AYT, Agrawal I, Ho WY, Yen YC, Pinter AJ, Liu J, Phua QXC, Koh KB, Chang JC, Sanford E, Man JHK, Wong P, Gutmann DH, Tucker-Kellogg G, Ling SC. Peng AYT, et al. Among authors: chang jc. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29101-29112. doi: 10.1073/pnas.2007806117. Epub 2020 Oct 30. Proc Natl Acad Sci U S A. 2020. PMID: 33127758 Free PMC article.
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. Ling SC, et al. Among authors: chang jc. Elife. 2019 Feb 12;8:e40811. doi: 10.7554/eLife.40811. Elife. 2019. PMID: 30747709 Free PMC article.
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC. Ho WY, et al. Among authors: chang jc. J Cell Biol. 2021 Sep 6;220(9):e201910213. doi: 10.1083/jcb.201910213. Epub 2021 Aug 4. J Cell Biol. 2021. PMID: 34347016 Free PMC article.
FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons.
Ho WY, Chak LL, Hor JH, Liu F, Diaz-Garcia S, Chang JC, Sanford E, Rodriguez MJ, Alagappan D, Lim SM, Cho YL, Shimizu Y, Sun AX, Tyan SH, Koo E, Kim SH, Ravits J, Ng SY, Okamura K, Ling SC. Ho WY, et al. Among authors: chang jc. iScience. 2023 Oct 6;26(11):108152. doi: 10.1016/j.isci.2023.108152. eCollection 2023 Nov 17. iScience. 2023. PMID: 37920668 Free PMC article.
Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression.
Zhang R, Rodriguez-Rodriguez P, Medrihan L, Chang JC, Ferraro T, Del Cioppo Vasques P, Wang W, Menard C, Cathomas F, Chan KL, Parise L, Shaham S, Roussarie JP, Troyanskaya O, Russo SJ, Milosevic A. Zhang R, et al. Among authors: chang jc. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630684. doi: 10.1101/2024.12.30.630684. bioRxiv. 2024. PMID: 39803419 Free PMC article. Preprint.
Erinacine A-Enriched Hericium erinaceus Mycelium Ethanol Extract Lessens Cellular Damage in Cell and Drosophila Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation.
Wu YL, Sun HL, Chang JC, Lin WY, Chen PY, Chen CC, Lee LY, Li CC, Hsieh M, Chen HW, Yang YC, Liu CS, Liu KL. Wu YL, et al. Among authors: chang jc. Antioxidants (Basel). 2024 Dec 7;13(12):1495. doi: 10.3390/antiox13121495. Antioxidants (Basel). 2024. PMID: 39765823 Free PMC article.
1,303 results