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Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response.
Montesion M, Murugesan K, Jin DX, Sharaf R, Sanchez N, Guria A, Minker M, Li G, Fisher V, Sokol ES, Pavlick DC, Moore JA, Braly A, Singal G, Fabrizio D, Comment LA, Rizvi NA, Alexander BM, Frampton GM, Hegde PS, Albacker LA. Montesion M, et al. Among authors: alexander bm. Cancer Discov. 2021 Feb;11(2):282-292. doi: 10.1158/2159-8290.CD-20-0672. Epub 2020 Oct 30. Cancer Discov. 2021. PMID: 33127846
Mechanisms and therapeutic implications of hypermutation in gliomas.
Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL. Touat M, et al. Among authors: alexander bm. Nature. 2020 Apr;580(7804):517-523. doi: 10.1038/s41586-020-2209-9. Epub 2020 Apr 15. Nature. 2020. PMID: 32322066 Free PMC article.
Frequent inactivating mutations of the PBAF complex gene PBRM1 in meningioma with papillary features.
Williams EA, Wakimoto H, Shankar GM, Barker FG 2nd, Brastianos PK, Santagata S, Sokol ES, Pavlick DC, Shah N, Reddy A, Venstrom JM, Alexander BM, Ross JS, Cahill DP, Ramkissoon SH, Juratli TA. Williams EA, et al. Among authors: alexander bm. Acta Neuropathol. 2020 Jul;140(1):89-93. doi: 10.1007/s00401-020-02161-7. Epub 2020 May 13. Acta Neuropathol. 2020. PMID: 32405805 No abstract available.
Pan-sarcoma genomic analysis of KMT2A rearrangements reveals distinct subtypes defined by YAP1-KMT2A-YAP1 and VIM-KMT2A fusions.
Massoth LR, Hung YP, Nardi V, Nielsen GP, Hasserjian RP, Louissaint A Jr, Fisch AS, Deshpande V, Zukerberg LR, Lennerz JK, Selig M, Glomski K, Patel PJ, Williams KJ, Sokol ES, Alexander BM, Vergilio JA, Ross JS, Pavlick DC, Chebib I, Williams EA. Massoth LR, et al. Among authors: alexander bm. Mod Pathol. 2020 Nov;33(11):2307-2317. doi: 10.1038/s41379-020-0582-4. Epub 2020 May 27. Mod Pathol. 2020. PMID: 32461620 Free PMC article.
CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.
Williams EA, Montesion M, Sharaf R, Corines J, Patel PJ, Gillespie BJ, Pavlick DC, Sokol ES, Alexander BM, Williams KJ, Elvin JA, Ross JS, Ramkissoon SH, Hemmerich AC, Tse JY, Mochel MC. Williams EA, et al. Among authors: alexander bm. Mod Pathol. 2020 Dec;33(12):2614-2625. doi: 10.1038/s41379-020-0584-2. Epub 2020 May 27. Mod Pathol. 2020. PMID: 32461623 Free PMC article.
Evidence-Based Development and Clinical Use of Precision Oncology Therapeutics.
Comment LA, Ward AF, Schrock AB, Fabrizio D, Venstrom JM, Hegde PS, Alexander BM. Comment LA, et al. Among authors: alexander bm. Clin Pharmacol Ther. 2020 Sep;108(3):440-443. doi: 10.1002/cpt.1967. Epub 2020 Aug 3. Clin Pharmacol Ther. 2020. PMID: 32744335 Free PMC article. No abstract available.
Retrospective analysis of real-world data to determine clinical outcomes of patients with advanced non-small cell lung cancer following cell-free circulating tumor DNA genomic profiling.
Madison R, Schrock AB, Castellanos E, Gregg JP, Snider J, Ali SM, Miller VA, Singal G, Alexander BM, Venstrom JM, Chung JH. Madison R, et al. Among authors: alexander bm. Lung Cancer. 2020 Oct;148:69-78. doi: 10.1016/j.lungcan.2020.07.033. Epub 2020 Aug 6. Lung Cancer. 2020. PMID: 32823229 Free article.
Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer.
Huang RSP, Li X, Haberberger J, Sokol E, Severson E, Duncan DL, Hemmerich A, Edgerly C, Williams E, Elvin J, Vergilio JA, Killian JK, Lin D, Hiemenz M, Xiao J, McEwan D, Holmes O, Danziger N, Erlich R, Frampton G, Cohen MB, McGregor K, Reddy P, Cardeiro D, Anhorn R, Venstrom J, Alexander B, Brown C, Pusztai L, Ross JS, Ramkissoon SH. Huang RSP, et al. Oncologist. 2020 Nov;25(11):943-953. doi: 10.1634/theoncologist.2020-0449. Epub 2020 Sep 14. Oncologist. 2020. PMID: 32869930 Free PMC article.
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