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Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model.
Parihar M, Dodds SG, Hubbard G, Javors MA, Strong R, Hasty P, Sharp ZD. Parihar M, et al. Among authors: hasty p. Clin Colorectal Cancer. 2021 Mar;20(1):e61-e70. doi: 10.1016/j.clcc.2020.08.006. Epub 2020 Sep 15. Clin Colorectal Cancer. 2021. PMID: 33132009 Free PMC article.
mTORC1 and p53: clash of the gods?
Hasty P, Sharp ZD, Curiel TJ, Campisi J. Hasty P, et al. Cell Cycle. 2013 Jan 1;12(1):20-5. doi: 10.4161/cc.22912. Cell Cycle. 2013. PMID: 23255104 Free PMC article.
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.
Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Livi CB, et al. Among authors: hasty p. Aging (Albany NY). 2013 Feb;5(2):100-10. doi: 10.18632/aging.100533. Aging (Albany NY). 2013. PMID: 23454836 Free PMC article.
eRapa restores a normal life span in a FAP mouse model.
Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. Hasty P, et al. Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26. Cancer Prev Res (Phila). 2014. PMID: 24282255 Free PMC article.
p53 and rapamycin are additive.
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. Christy B, et al. Among authors: hasty p. Oncotarget. 2015 Jun 30;6(18):15802-13. doi: 10.18632/oncotarget.4602. Oncotarget. 2015. PMID: 26158292 Free PMC article.
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Hurez V, et al. Among authors: hasty p. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. Aging Cell. 2015. PMID: 26315673 Free PMC article.
108 results