Lehner PJ - Search Results

1

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

van den Boomen DJH, Sienkiewicz A, Berlin I, Jongsma MLM, van Elsland DM, Luzio JP, Neefjes JJC, Lehner PJ. van den Boomen DJH, et al. Among authors: lehner pj. Nat Commun. 2020 Nov 3;11(1):5559. doi: 10.1038/s41467-020-19032-0. Nat Commun. 2020. PMID: 33144569 Free PMC article.

2

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells.

MacAry PA, Lindsay M, Scott MA, Craig JI, Luzio JP, Lehner PJ. MacAry PA, et al. Among authors: lehner pj. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3982-7. doi: 10.1073/pnas.071477498. Proc Natl Acad Sci U S A. 2001. PMID: 11274420 Free PMC article.

3

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.

Bowers K, Piper SC, Edeling MA, Gray SR, Owen DJ, Lehner PJ, Luzio JP. Bowers K, et al. Among authors: lehner pj. J Biol Chem. 2006 Feb 24;281(8):5094-105. doi: 10.1074/jbc.M508632200. Epub 2005 Dec 20. J Biol Chem. 2006. PMID: 16371348 Free article.

4

Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.

Duncan LM, Piper S, Dodd RB, Saville MK, Sanderson CM, Luzio JP, Lehner PJ. Duncan LM, et al. Among authors: lehner pj. EMBO J. 2006 Apr 19;25(8):1635-45. doi: 10.1038/sj.emboj.7601056. Epub 2006 Apr 6. EMBO J. 2006. PMID: 16601694 Free PMC article.

5

ESCRT proteins and the regulation of endocytic delivery to lysosomes.

Luzio JP, Piper SC, Bowers K, Parkinson MD, Lehner PJ, Bright NA. Luzio JP, et al. Among authors: lehner pj. Biochem Soc Trans. 2009 Feb;37(Pt 1):178-80. doi: 10.1042/BST0370178. Biochem Soc Trans. 2009. PMID: 19143626

6

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ. Stagg HR, et al. Among authors: lehner pj. J Cell Biol. 2009 Sep 7;186(5):685-92. doi: 10.1083/jcb.200906110. Epub 2009 Aug 31. J Cell Biol. 2009. PMID: 19720873 Free PMC article.

7

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Burr ML, van den Boomen DJ, Bye H, Antrobus R, Wiertz EJ, Lehner PJ. Burr ML, et al. Among authors: lehner pj. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14290-5. doi: 10.1073/pnas.1303380110. Epub 2013 Aug 8. Proc Natl Acad Sci U S A. 2013. PMID: 23929775 Free PMC article.

8

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ. van den Boomen DJ, et al. Among authors: lehner pj. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16. Proc Natl Acad Sci U S A. 2014. PMID: 25030448 Free PMC article.

9

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Hsu JL, van den Boomen DJ, Tomasec P, Weekes MP, Antrobus R, Stanton RJ, Ruckova E, Sugrue D, Wilkie GS, Davison AJ, Wilkinson GW, Lehner PJ. Hsu JL, et al. Among authors: lehner pj. PLoS Pathog. 2015 Apr 14;11(4):e1004811. doi: 10.1371/journal.ppat.1004811. eCollection 2015 Apr. PLoS Pathog. 2015. PMID: 25875600 Free PMC article.

10

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.

van den Boomen DJ, Lehner PJ. van den Boomen DJ, et al. Among authors: lehner pj. Mol Immunol. 2015 Dec;68(2 Pt A):106-11. doi: 10.1016/j.molimm.2015.07.005. Epub 2015 Jul 22. Mol Immunol. 2015. PMID: 26210183 Free PMC article. Review.

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