Whittaker GR - Search Results

1

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.

Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N. Ghosh S, et al. Among authors: whittaker gr. Cell. 2020 Dec 10;183(6):1520-1535.e14. doi: 10.1016/j.cell.2020.10.039. Epub 2020 Oct 27. Cell. 2020. PMID: 33157038 Free PMC article.

2

A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site.

Straus MR, Whittaker GR. Straus MR, et al. Among authors: whittaker gr. PLoS One. 2017 Mar 30;12(3):e0174827. doi: 10.1371/journal.pone.0174827. eCollection 2017. PLoS One. 2017. PMID: 28358853 Free PMC article.

3

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation.

Jaimes JA, Millet JK, Goldstein ME, Whittaker GR, Straus MR. Jaimes JA, et al. Among authors: whittaker gr. J Vis Exp. 2019 Jan 9;(143). doi: 10.3791/58892. J Vis Exp. 2019. PMID: 30688313

4

Calcium Ions Directly Interact with the Ebola Virus Fusion Peptide To Promote Structure-Function Changes That Enhance Infection.

Nathan L, Lai AL, Millet JK, Straus MR, Freed JH, Whittaker GR, Daniel S. Nathan L, et al. Among authors: whittaker gr. ACS Infect Dis. 2020 Feb 14;6(2):250-260. doi: 10.1021/acsinfecdis.9b00296. Epub 2019 Dec 10. ACS Infect Dis. 2020. PMID: 31746195 Free PMC article.

5

Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell culture.

Whittaker GR, Straus MR. Whittaker GR, et al. Influenza Other Respir Viruses. 2020 Mar;14(2):189-195. doi: 10.1111/irv.12707. Epub 2019 Dec 9. Influenza Other Respir Viruses. 2020. PMID: 31820577 Free PMC article.

6

SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses.

Straus MR, Kinder JT, Segall M, Dutch RE, Whittaker GR. Straus MR, et al. Among authors: whittaker gr. Virology. 2020 Apr;543:43-53. doi: 10.1016/j.virol.2020.01.004. Epub 2020 Jan 7. Virology. 2020. PMID: 32056846 Free PMC article.

7

Ca²⁺ Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity.

Straus MR, Tang T, Lai AL, Flegel A, Bidon M, Freed JH, Daniel S, Whittaker GR. Straus MR, et al. Among authors: whittaker gr. J Virol. 2020 Jun 16;94(13):e00426-20. doi: 10.1128/JVI.00426-20. Print 2020 Jun 16. J Virol. 2020. PMID: 32295925 Free PMC article.

8

Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles.

Chen CZ, Xu M, Pradhan M, Gorshkov K, Petersen JD, Straus MR, Zhu W, Shinn P, Guo H, Shen M, Klumpp-Thomas C, Michael SG, Zimmerberg J, Zheng W, Whittaker GR. Chen CZ, et al. Among authors: whittaker gr. ACS Pharmacol Transl Sci. 2020 Oct 19;3(6):1165-1175. doi: 10.1021/acsptsci.0c00112. eCollection 2020 Dec 11. ACS Pharmacol Transl Sci. 2020. PMID: 33330839 Free PMC article.

9

Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin.

Tang T, Jaimes JA, Bidon MK, Straus MR, Daniel S, Whittaker GR. Tang T, et al. Among authors: whittaker gr. ACS Infect Dis. 2021 Feb 12;7(2):264-272. doi: 10.1021/acsinfecdis.0c00701. Epub 2021 Jan 12. ACS Infect Dis. 2021. PMID: 33432808

10

Inhibitors of L-Type Calcium Channels Show Therapeutic Potential for Treating SARS-CoV-2 Infections by Preventing Virus Entry and Spread.

Straus MR, Bidon MK, Tang T, Jaimes JA, Whittaker GR, Daniel S. Straus MR, et al. Among authors: whittaker gr. ACS Infect Dis. 2021 Oct 8;7(10):2807-2815. doi: 10.1021/acsinfecdis.1c00023. Epub 2021 Sep 9. ACS Infect Dis. 2021. PMID: 34498840

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