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Page 1
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP. Obraztsova K, et al. Nat Commun. 2020 Nov 6;11(1):5640. doi: 10.1038/s41467-020-18979-4. Nat Commun. 2020. PMID: 33159078 Free PMC article.
Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors.
Stepanova V, Dergilev KV, Holman KR, Parfyonova YV, Tsokolaeva ZI, Teter M, Atochina-Vasserman EN, Volgina A, Zaitsev SV, Lewis SP, Zabozlaev FG, Obraztsova K, Krymskaya VP, Cines DB. Stepanova V, et al. Among authors: obraztsova k. J Biol Chem. 2017 Dec 15;292(50):20528-20543. doi: 10.1074/jbc.M117.799593. Epub 2017 Sep 27. J Biol Chem. 2017. PMID: 28972182 Free PMC article.
Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis.
Maisel K, Merrilees MJ, Atochina-Vasserman EN, Lian L, Obraztsova K, Rue R, Vasserman AN, Zuo N, Angel LF, Gow AJ, Kang I, Wight TN, Eruslanov E, Swartz MA, Krymskaya VP. Maisel K, et al. Among authors: obraztsova k. Am J Respir Cell Mol Biol. 2018 Dec;59(6):723-732. doi: 10.1165/rcmb.2018-0123OC. Am J Respir Cell Mol Biol. 2018. PMID: 30095976 Free PMC article.
Syndecan-2: Old Player in a New Field.
Obraztsova K, Evans J, Krymskaya VP. Obraztsova K, et al. Am J Respir Cell Mol Biol. 2019 Jun;60(6):611-612. doi: 10.1165/rcmb.2019-0033ED. Am J Respir Cell Mol Biol. 2019. PMID: 30896971 Free PMC article. No abstract available.
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling.
Lin SM, Rue R, Mukhitov AR, Goel A, Basil MC, Obraztsova K, Babu A, Crnkovic S, Ledwell OA, Ferguson LT, Planer JD, Nottingham AN, Vanka KS, Smith CJ, Cantu E 3rd, Kwapiszewska G, Morrisey EE, Evans JF, Krymskaya VP. Lin SM, et al. Among authors: obraztsova k. J Clin Invest. 2023 Dec 20;134(4):e172116. doi: 10.1172/JCI172116. J Clin Invest. 2023. PMID: 38127441 Free PMC article.
Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung.
Villaseñor-Altamirano AB, Jain D, Jeong Y, Menon JA, Kamiya M, Haider H, Manandhar R, Sheikh MDA, Athar H, Merriam LT, Ryu MH, Sasaki T, Castaldi PJ, Rao DA, Sholl LM, Vivero M, Hersh CP, Zhou X, Veerkamp J, Yun JH, Kim EY; MassGeneralBrigham - Bayer Pulmonary Drug Discovery Laboratory. Villaseñor-Altamirano AB, et al. Am J Respir Crit Care Med. 2023 Dec 1;208(11):1177-1195. doi: 10.1164/rccm.202305-0924OC. Am J Respir Crit Care Med. 2023. PMID: 37756440 Free PMC article.
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