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Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells.
Shigesaka M, Ito T, Inaba M, Imai K, Yamanaka H, Azuma Y, Tanaka A, Amuro H, Nishizawa T, Son Y, Satake A, Ozaki Y, Nomura S. Shigesaka M, et al. Among authors: inaba m. Arthritis Res Ther. 2020 Nov 9;22(1):264. doi: 10.1186/s13075-020-02356-z. Arthritis Res Ther. 2020. PMID: 33168076 Free PMC article.
Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production.
Amuro H, Ito T, Miyamoto R, Sugimoto H, Torii Y, Son Y, Nakamichi N, Yamazaki C, Hoshino K, Kaisho T, Ozaki Y, Inaba M, Amakawa R, Fukuhara S. Amuro H, et al. Among authors: inaba m. Arthritis Rheum. 2010 Jul;62(7):2073-85. doi: 10.1002/art.27478. Arthritis Rheum. 2010. PMID: 20506142 Free article.
1,575 results