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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: doolittle ml. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers.
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell RGG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, LeBrasseur NK, Farr JN, Robbins PD, Khosla S. Samakkarnthai P, et al. Among authors: doolittle ml. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529777. doi: 10.1101/2023.02.23.529777. bioRxiv. 2023. Update in: Aging (Albany NY). 2023 May 7;15(9):3331-3355. doi: 10.18632/aging.204701 PMID: 36865244 Free PMC article. Updated. Preprint.
Distinct secretomes in p16- and p21- positive senescent cells across tissues.
Saul D, Jurk D, Doolittle ML, Kosinsky RL, Monroe DG, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF. Saul D, et al. Among authors: doolittle ml. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.569858. doi: 10.1101/2023.12.05.569858. bioRxiv. 2023. PMID: 38106149 Free PMC article. Preprint.
Targeting the gut microbiome to treat the osteoarthritis of obesity.
Schott EM, Farnsworth CW, Grier A, Lillis JA, Soniwala S, Dadourian GH, Bell RD, Doolittle ML, Villani DA, Awad H, Ketz JP, Kamal F, Ackert-Bicknell C, Ashton JM, Gill SR, Mooney RA, Zuscik MJ. Schott EM, et al. Among authors: doolittle ml. JCI Insight. 2018 Apr 19;3(8):e95997. doi: 10.1172/jci.insight.95997. eCollection 2018 Apr 19. JCI Insight. 2018. PMID: 29669931 Free PMC article.
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. Saul D, et al. Among authors: doolittle ml. Nat Commun. 2022 Aug 16;13(1):4827. doi: 10.1038/s41467-022-32552-1. Nat Commun. 2022. PMID: 35974106 Free PMC article.
Osteocyte Cellular Senescence.
Farr JN, Kaur J, Doolittle ML, Khosla S. Farr JN, et al. Among authors: doolittle ml. Curr Osteoporos Rep. 2020 Oct;18(5):559-567. doi: 10.1007/s11914-020-00619-x. Curr Osteoporos Rep. 2020. PMID: 32794138 Free PMC article. Review.
26 results