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The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: egan cl. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.
Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA. Whitham M, et al. Among authors: egan cl. Cell Metab. 2018 Jan 9;27(1):237-251.e4. doi: 10.1016/j.cmet.2017.12.001. Cell Metab. 2018. PMID: 29320704 Free article. Clinical Trial.
Adipocyte-specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice.
Whitham M, Pal M, Petzold T, Hjorth M, Egan CL, Brunner JS, Estevez E, Iliades P, Zivanovic B, Reibe S, Hughes WE, Findeisen M, Hidalgo J, Febbraio MA. Whitham M, et al. Among authors: egan cl. Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E597-E604. doi: 10.1152/ajpendo.00206.2019. Epub 2019 Aug 6. Am J Physiol Endocrinol Metab. 2019. PMID: 31386565 Free article.
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA. Findeisen M, et al. Nature. 2019 Oct;574(7776):63-68. doi: 10.1038/s41586-019-1601-9. Epub 2019 Sep 25. Nature. 2019. PMID: 31554967
Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice.
Hjorth M, Egan CL, Telles GD, Pal M, Gallego-Ortega D, Fuller OK, McLennan ED, Gillis RD, Oh TG, Muscat GEO, Tegegne S, Mah MS, Skhinas J, Estevez E, Adams TE, McKay MJ, Molloy M, Watt KI, Qian H, Gregorevic P, Cox TR, Hojman P, Midtgaard J, Christensen JF, Friedrichsen M, Iozzo RV, Sloan EK, Drew BG, Wojtaszewski JFP, Whitham M, Febbraio MA. Hjorth M, et al. Among authors: egan cl. J Sport Health Sci. 2024 Sep 26:100991. doi: 10.1016/j.jshs.2024.100991. Online ahead of print. J Sport Health Sci. 2024. PMID: 39341495 Free article.
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Among authors: egan cl. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
The utility of the TRUE test in a private practice setting.
Militello G, Woo DK, Kantor J, Egan CL, Solotoff SA, Spiers EM, Stierstorfer MB, James WD. Militello G, et al. Among authors: egan cl. Dermatitis. 2006 Jun;17(2):77-84. Dermatitis. 2006. PMID: 16956457
22 results