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The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: estevez e. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice.
Lindegaard B, Matthews VB, Brandt C, Hojman P, Allen TL, Estevez E, Watt MJ, Bruce CR, Mortensen OH, Syberg S, Rudnicka C, Abildgaard J, Pilegaard H, Hidalgo J, Ditlevsen S, Alsted TJ, Madsen AN, Pedersen BK, Febbraio MA. Lindegaard B, et al. Among authors: estevez e. Diabetes. 2013 Sep;62(9):3064-74. doi: 10.2337/db12-1095. Epub 2013 May 13. Diabetes. 2013. PMID: 23670974 Free PMC article.
Targeting gp130 to prevent inflammation and promote insulin action.
Kraakman MJ, Allen TL, Whitham M, Iliades P, Kammoun HL, Estevez E, Lancaster GI, Febbraio MA. Kraakman MJ, et al. Among authors: estevez e. Diabetes Obes Metab. 2013 Sep;15 Suppl 3:170-5. doi: 10.1111/dom.12170. Diabetes Obes Metab. 2013. PMID: 24003934 Review.
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.
Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC. Mauer J, et al. Among authors: estevez e. Nat Immunol. 2014 May;15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30. Nat Immunol. 2014. PMID: 24681566 Free PMC article.
Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance.
Henstridge DC, Estevez E, Allen TL, Heywood SE, Gardner T, Yang C, Mellett NA, Kingwell BA, Meikle PJ, Febbraio MA. Henstridge DC, et al. Among authors: estevez e. Cell Stress Chaperones. 2015 May;20(3):461-72. doi: 10.1007/s12192-015-0571-6. Epub 2015 Jan 25. Cell Stress Chaperones. 2015. PMID: 25618331 Free PMC article.
Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice.
Jordy AB, Kraakman MJ, Gardner T, Estevez E, Kammoun HL, Weir JM, Kiens B, Meikle PJ, Febbraio MA, Henstridge DC. Jordy AB, et al. Among authors: estevez e. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E778-91. doi: 10.1152/ajpendo.00547.2014. Epub 2015 Feb 24. Am J Physiol Endocrinol Metab. 2015. PMID: 25714675 Free article.
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA. Kraakman MJ, et al. Among authors: estevez e. Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Cell Metab. 2015. PMID: 25738456 Free article.
132 results