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The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: hajto a. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Lipid scavenging macrophages and inflammation.
Vogel A, Brunner JS, Hajto A, Sharif O, Schabbauer G. Vogel A, et al. Among authors: hajto a. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159066. doi: 10.1016/j.bbalip.2021.159066. Epub 2021 Oct 6. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34626791 Free article. Review.
Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis.
Kieler M, Prammer LS, Heller G, Hofmann M, Sperger S, Hanetseder D, Niederreiter B, Komljenovic A, Klavins K, Köcher T, Brunner JS, Stanic I, Oberbichler L, Korosec A, Vogel A, Kerndl M, Hromadová D, Musiejovsky L, Hajto A, Dobrijevic A, Piwonka T, Haschemi A, Miller A, Georgel P, Marolt Presen D, Grillari J, Hayer S, Auger JP, Krönke G, Sharif O, Aletaha D, Schabbauer G, Blüml S. Kieler M, et al. Among authors: hajto a. Ann Rheum Dis. 2024 Oct 21;83(11):1465-1479. doi: 10.1136/ard-2023-224898. Ann Rheum Dis. 2024. PMID: 38986577 Free PMC article.