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The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: schweiger m. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R. Schweiger M, et al. Nat Commun. 2017 Mar 22;8:14859. doi: 10.1038/ncomms14859. Nat Commun. 2017. PMID: 28327588 Free PMC article.
CD8+ T cells induce cachexia during chronic viral infection.
Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. Baazim H, et al. Among authors: schweiger m. Nat Immunol. 2019 Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. Nat Immunol. 2019. PMID: 31110314 Free PMC article.
An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia.
Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, Schauer S, Baumgartner VJ, Grabner GF, Schabbauer G, Wolinski H, Robertson GR, Hoefler G, Zeng W, Wagner EF, Schweiger M, Zechner R. Xie H, et al. Among authors: schweiger m. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112840119. doi: 10.1073/pnas.2112840119. Proc Natl Acad Sci U S A. 2022. PMID: 35210363 Free PMC article.
Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia.
Pototschnig I, Feiler U, Diwoky C, Vesely PW, Rauchenwald T, Paar M, Bakiri L, Pajed L, Hofer P, Kashofer K, Sukhbaatar N, Schoiswohl G, Weichhart T, Hoefler G, Bock C, Pichler M, Wagner EF, Zechner R, Schweiger M. Pototschnig I, et al. Among authors: schweiger m. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):93-107. doi: 10.1002/jcsm.13109. Epub 2022 Nov 9. J Cachexia Sarcopenia Muscle. 2023. PMID: 36351437 Free PMC article.
R-ketorolac ameliorates cancer-associated cachexia and prolongs survival of tumour-bearing mice.
Chrysostomou SE, Eder S, Pototschnig I, Mayer AL, Derler M, Mussbacher M, Schauer S, Zhang D, Yan D, Liu G, Hoefler G, Weichhart T, Vesely PW, Zhang L, Schweiger M. Chrysostomou SE, et al. Among authors: schweiger m. J Cachexia Sarcopenia Muscle. 2024 Apr;15(2):562-574. doi: 10.1002/jcsm.13422. Epub 2024 Feb 1. J Cachexia Sarcopenia Muscle. 2024. PMID: 38302863 Free PMC article.
679 results