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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Visnes T, Benítez-Buelga C, Cázares-Körner A, Sanjiv K, Hanna BMF, Mortusewicz O, Rajagopal V, Albers JJ, Hagey DW, Bekkhus T, Eshtad S, Baquero JM, Masuyer G, Wallner O, Müller S, Pham T, Göktürk C, Rasti A, Suman S, Torres-Ruiz R, Sarno A, Wiita E, Homan EJ, Karsten S, Marimuthu K, Michel M, Koolmeister T, Scobie M, Loseva O, Almlöf I, Unterlass JE, Pettke A, Boström J, Pandey M, Gad H, Herr P, Jemth AS, El Andaloussi S, Kalderén C, Rodriguez-Perales S, Benítez J, Krokan HE, Altun M, Stenmark P, Berglund UW, Helleday T. Visnes T, et al. Among authors: muller s. Nucleic Acids Res. 2020 Dec 2;48(21):12234-12251. doi: 10.1093/nar/gkaa1048. Nucleic Acids Res. 2020. PMID: 33211885 Free PMC article.
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects.
Baquero JM, Benítez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Müller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodríguez-Perales S, Gad H, Visnes T, Helleday T, Benítez J, Osorio A. Baquero JM, et al. Among authors: muller s. Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7. Sci Rep. 2021. PMID: 33568707 Free PMC article.
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M, Benítez-Buelga C, Calvo PA, Hanna BMF, Mortusewicz O, Masuyer G, Davies J, Wallner O, Sanjiv K, Albers JJ, Castañeda-Zegarra S, Jemth AS, Visnes T, Sastre-Perona A, Danda AN, Homan EJ, Marimuthu K, Zhenjun Z, Chi CN, Sarno A, Wiita E, von Nicolai C, Komor AJ, Rajagopal V, Müller S, Hank EC, Varga M, Scaletti ER, Pandey M, Karsten S, Haslene-Hox H, Loevenich S, Marttila P, Rasti A, Mamonov K, Ortis F, Schömberg F, Loseva O, Stewart J, D'Arcy-Evans N, Koolmeister T, Henriksson M, Michel D, de Ory A, Acero L, Calvete O, Scobie M, Hertweck C, Vilotijevic I, Kalderén C, Osorio A, Perona R, Stolz A, Stenmark P, Berglund UW, de Vega M, Helleday T. Michel M, et al. Among authors: muller s. Science. 2022 Jun 24;376(6600):1471-1476. doi: 10.1126/science.abf8980. Epub 2022 Jun 23. Science. 2022. PMID: 35737787
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
Ramani A, Pasquini G, Gerkau NJ, Jadhav V, Vinchure OS, Altinisik N, Windoffer H, Muller S, Rothenaigner I, Lin S, Mariappan A, Rathinam D, Mirsaidi A, Goureau O, Ricci-Vitiani L, D'Alessandris QG, Wollnik B, Muotri A, Freifeld L, Jurisch-Yaksi N, Pallini R, Rose CR, Busskamp V, Gabriel E, Hadian K, Gopalakrishnan J. Ramani A, et al. Among authors: muller s. Nat Commun. 2024 Dec 19;15(1):10703. doi: 10.1038/s41467-024-55226-6. Nat Commun. 2024. PMID: 39702477 Free PMC article.
Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations.
Stroeks SLVM, Muller S, Beelen NJ, Venner MFGHM, Baas AF, van Empel VPM, Krapels IPC, Hazebroek MR, Te Riele ASJM, Verdonschot JAJ. Stroeks SLVM, et al. Among authors: muller s. Circ Genom Precis Med. 2025 Jan 22:e004778. doi: 10.1161/CIRCGEN.124.004778. Online ahead of print. Circ Genom Precis Med. 2025. PMID: 39840450 No abstract available.
Yield of family screening for dilated cardiomyopathy: 10-year experience at a multidisciplinary cardiogenetic outpatient clinic.
Thierry IP, Muller SA, Baas AF, Dooijes D, van Loon RLE, Schoemaker AE, van der Harst P, Oerlemans MIFJ, Baars HF, Hassink RJ, Asselbergs FW, van Tintelen JP, Te Riele ASJM. Thierry IP, et al. Among authors: muller sa. Neth Heart J. 2025 Jan 20. doi: 10.1007/s12471-024-01924-1. Online ahead of print. Neth Heart J. 2025. PMID: 39833651
The role of 18F-FDG PET/CT in detecting synchronous regional and distant metastatic disease in patients with an in-breast tumour recurrence.
Walstra CJEF, Schipper RJ, Voogd AC, van der Sangen MJC, van Duin RTNW, van Riet YE, Smidt ML, Bloemen JG, Wyndaele DNJ, Nieuwenhuijzen GAP; Dutch Snapshot Research Group. Walstra CJEF, et al. Eur J Surg Oncol. 2024 Dec 24;51(5):109564. doi: 10.1016/j.ejso.2024.109564. Online ahead of print. Eur J Surg Oncol. 2024. PMID: 39826447
Publisher Correction: TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation.
Nutsch K, Banta KL, Wu TD, Tran CW, Mittman S, Duong E, Nabet BY, Qu Y, Williams K, Müller S, Patil NS, Chiang EY, Mellman I. Nutsch K, et al. Among authors: muller s. Nat Cancer. 2025 Jan 17. doi: 10.1038/s43018-025-00908-3. Online ahead of print. Nat Cancer. 2025. PMID: 39825000 No abstract available.
5,713 results